{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T14:40:03Z","timestamp":1784385603805,"version":"3.55.0"},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,4,13]],"date-time":"2025-04-13T00:00:00Z","timestamp":1744502400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["24fk0210108"],"award-info":[{"award-number":["24fk0210108"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["22K16535"],"award-info":[{"award-number":["22K16535"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["23H02981"],"award-info":[{"award-number":["23H02981"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Annals of Gastroent Surgery"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Liver fibrosis is a key factor in the progression of chronic liver diseases, including viral hepatitis and metabolic dysfunction\u2010associated steatotic liver disease. If untreated, fibrosis can progress to cirrhosis, increasing the risk of liver cancer or failure. This study evaluates the Fibrosis (FIB)\u20103 index, a novel marker free from age\u2010related biases, for predicting liver fibrosis and 5\u2010year outcomes in hepatocellular carcinoma (HCC) patients undergoing hepatectomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data from 1013 patients who underwent liver resection were analyzed in this multi\u2010institutional study. The predictive performance of the FIB\u20103 index was compared with the original FIB\u20104 index, which incorporates age into its calculation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The FIB\u20103 index demonstrated superior accuracy for advanced fibrosis (\u2265F3) in elderly patients. A higher FIB\u20103 index was an independent risk factor for recurrence\u2010free survival in elderly patients, underscoring its utility in this population. Notably, the application of appropriate cutoff values allowed the FIB\u20103 index to facilitate effective risk stratification for 5\u2010year overall survival and recurrence\u2010free survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The FIB\u20103 index served as an effective alternative to the FIB\u20104 index in assessing liver fibrosis among aged patients, and it effectively stratified the likelihood of the 5\u2010year outcomes when utilized in conjunction with a specific cut\u2010off after initial hepatectomy for HCC.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ags3.70010","type":"journal-article","created":{"date-parts":[[2025,4,13]],"date-time":"2025-04-13T19:44:01Z","timestamp":1744573441000},"page":"1055-1065","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["FIB\u20103 index as a novel age\u2010independent predictor of liver fibrosis and prognosis in hepatocellular carcinoma patients undergoing hepatectomy"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0882-5341","authenticated-orcid":false,"given":"Yuki","family":"Imaoka","sequence":"first","affiliation":[{"name":"Department of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health Sciences Hiroshima University Hiroshima University  Hiroshima Japan"},{"name":"Division of Abdominal Transplant Stanford University  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5433-5303","authenticated-orcid":false,"given":"Masahiro","family":"Ohira","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health Sciences Hiroshima University Hiroshima University  Hiroshima Japan"},{"name":"Division of Regeneration and Medicine, Medical Center for Translational and Clinical Research Hiroshima University 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