{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T13:06:42Z","timestamp":1785416802755,"version":"3.56.0"},"reference-count":22,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,4,3]],"date-time":"2025-04-03T00:00:00Z","timestamp":1743638400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Annals of Gastroent Surgery"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>There is a lack of compelling evidence supporting the benefit of surgical resection for para\u2010aortic lymph node metastasis (PALNM) from colorectal cancer (CRC). We aimed to investigate the true impact of surgical resection on survival for patients with PALNM from CRC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p>Patients diagnosed with PALNM from CRC at the Japanese Society for Cancer of the Colon and Rectum institutions between January 2011 and December 2015 were analyzed. Those who had received surgical resection and those who did not were matched one\u2010on\u2010one by the propensity score (PS)\u2010matching method. A total of 77 PS\u2010matched pairs extracted from 347 patients at 36 institutions were compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010one (40.3%) patients each in the surgical resection and chemotherapy groups had distant metastasis other than PALNM, and the most dominant organ was the liver in 18 (23.4%) patients in both groups. In the surgical resection group, 56 (72.7%) patients achieved curative resection of all disease lesions, of which 49 (63.6%) were R0 resection. Three\u2010 and 5\u2010year relapse\u2010free survival of patients who achieved curative resection were 24.4% and 24.4%, respectively. Three\u2010 and 5\u2010year overall survival (OS) of patients in the surgical resection were 68.4% and 40.2%, which were significantly better than that in the chemotherapy groups (40.9% and 27.7%), respectively (Log\u2010rank <jats:italic>p<\/jats:italic>\u2009=\u20090.003).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The OS of patients with surgical resection for PALNM was significantly better than those without surgical resection. These results highlight the benefit of surgical intervention to survival for patients with resectable PALNM.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ags3.70019","type":"journal-article","created":{"date-parts":[[2025,4,5]],"date-time":"2025-04-05T06:17:52Z","timestamp":1743833872000},"page":"997-1007","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Does surgical intervention contribute to survival for patients with para\u2010aortic lymph node metastasis from colorectal cancer?"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0435-5370","authenticated-orcid":false,"given":"Akira","family":"Ouchi","sequence":"first","affiliation":[{"name":"Department of Gastroenterological Surgery Aichi Cancer Center Hospital  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6834-995X","authenticated-orcid":false,"given":"Koji","family":"Komori","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery Aichi Cancer Center Hospital  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sono","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery Tokyo Medical and Dental University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7885-2276","authenticated-orcid":false,"given":"Yusuke","family":"Kinugasa","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery Tokyo Medical and Dental University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soichiro","family":"Ishihara","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology The University of Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5657-8686","authenticated-orcid":false,"given":"Akio","family":"Shiomi","sequence":"additional","affiliation":[{"name":"Division of Colon and Rectal Surgery Shizuoka Cancer Center Hospital  Nagaizumi\u2010cho Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukihide","family":"Kanemitsu","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery National Cancer Center Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Suto","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery Yamagata Prefectural Central Hospital  Yamagata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery Nagoya City University Graduate School of Medical Sciences  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoichi","family":"Ajioka","sequence":"additional","affiliation":[{"name":"Division of Molecular and Diagnostic Pathology, Graduate School of Medical and Dental Science Niigata University  Niigata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the study group for PALNM projected by 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