{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T02:55:23Z","timestamp":1792205723845,"version":"4.4.0"},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,5,31]],"date-time":"2025-05-31T00:00:00Z","timestamp":1748649600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Annals of Gastroent Surgery"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Although the number of older people is increasing, there is a lack of evidence and insufficient consensus regarding postoperative complications and survival in older cancer patients. In this study, we conducted a literature search and systematic review focusing on the outcomes after surgery for older cancer patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Literature focusing on surgical treatment for older cancer patients was extracted from Japanese clinical practice guidelines for gastric cancer, lung cancer, colorectal cancer, liver cancer, and gynecological cancers (uterine body, uterine cervix, ovary, and external genitalia and vagina). Outcomes were reviewed, and committee members determined the strength of evidence on a four\u2010point scale (A to D), with A being the highest and D being the lowest.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Older cancer patients tend to have a higher incidence of postoperative complications and postoperative syndromes, and their expected survival is generally shorter compared to non\u2010older patients. When extensive surgeries such as para\u2010aortic lymph node dissection and\/or resection with other organs are performed for older cancer patients, the postoperative mortality rates tend to increase compared to non\u2010older patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Surgical treatments for older cancer patients tend to result in higher morbidity even when the patients are in good health status. Nevertheless, there is still a possibility that a certain fraction of the patients achieve treatment outcomes comparable to those of non\u2010older patients. Therefore, surgical indication and procedure for older cancer patients should be carefully determined based on surgical invasiveness and patient tolerability.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ags3.70048","type":"journal-article","created":{"date-parts":[[2025,5,31]],"date-time":"2025-05-31T09:34:17Z","timestamp":1748684057000},"page":"1128-1136","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Surgery for Older Cancer Patients: Cross\u2010Organ Review and Good Practice Statement by the Japanese Geriatric Oncology Guideline Committee"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7931-8753","authenticated-orcid":false,"given":"Chie","family":"Tanaka","sequence":"first","affiliation":[{"name":"Department of Gastroenterological Surgery Nagoya University Graduate School of Medicine  Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6219-5278","authenticated-orcid":false,"given":"Takashi","family":"Ofuchi","sequence":"additional","affiliation":[{"name":"Department of Surgery Kyushu University Beppu Hospital  Beppu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiichiro","family":"Ninomiya","sequence":"additional","affiliation":[{"name":"Center for Comprehensive Genomic Medicine Okayama University Hospital  Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Inoue","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Fukui  Fukui Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Sugimoto","sequence":"additional","affiliation":[{"name":"Department of General Geriatric Medicine Kawasaki Medical School  Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiko","family":"Murofushi","sequence":"additional","affiliation":[{"name":"Division of Radiation Oncology, Department of Radiology Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toru","family":"Okuyama","sequence":"additional","affiliation":[{"name":"Department of Psychiatry\/Palliative Care Center Nagoya City University West Medical Center  Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeaki","family":"Watanuki","sequence":"additional","affiliation":[{"name":"National Center for Global Health and Medicine National College of Nursing  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiyo","family":"Imamura","sequence":"additional","affiliation":[{"name":"Advanced Cancer Translational Research Institute Showa University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Sakai","sequence":"additional","affiliation":[{"name":"Department of Frontier Science for Cancer and Chemotherapy Osaka University Graduate School of Medicine  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naomi","family":"Sakurai","sequence":"additional","affiliation":[{"name":"Cancer Solutions Co. Ltd  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyotaka","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology, Department of Medicine, School of Medicine Teikyo University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuo","family":"Tamura","sequence":"additional","affiliation":[{"name":"NPO Clinical Hematology\/Oncology Treatment Study Group  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiaki","family":"Saeki","sequence":"additional","affiliation":[{"name":"Breast Oncology Service Saitama Medical University International Medical Center  Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Ishiguro","sequence":"additional","affiliation":[{"name":"Breast Oncology Service Saitama Medical University International Medical Center  Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,31]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"Ministry of Health Labour and Welfare \u201cAverage Life Expectancy Abridged Tables\u00a02020 \u201daccessed September 2 2022 https:\/\/www.mhlw.go.jp\/toukei\/saikin\/hw\/life\/life20\/dl\/life18\u201004.pdf."},{"key":"e_1_2_9_3_1","unstructured":"Cancer Registry and Statistics \u201cCancer Information Service Cancer Mortality From Vital Statistics in Japan (1958\u20132019) \u201dhttps:\/\/ganjoho.jp\/reg_stat\/statistics\/dI\/index.html."},{"key":"e_1_2_9_4_1","unstructured":"Cancer Registry and Statistics \u201cCancer Information Service National Cancer Registry in Japan (2016\u20132018) \u201d(2021) https:\/\/ganjoho.jp\/reg_stat\/statistics\/dI\/index.html."},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2021.4158"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2022.36149"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2022.35714"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-018-6391-x"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000003217"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-017-5851-1"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(18)30411-9"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2019.03.090"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2010.25.7.1034"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13304-020-00717-6"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/DCR.0b013e31819f5fa2"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2016.07.010"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10120-019-01000-3"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2009.06.004"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2012.11.052"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezt462"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e31815e8577"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e318290912d"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(99)70467-8"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-009-0736-6"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djn397"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.3802\/jgo.2015.26.2.134"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2011.06.031"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2015.10.015"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002680010277"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12282-023-01510-0"},{"key":"e_1_2_9_31_1","volume-title":"Clinical Practice Guidelines for Hepatocellular Carcinoma 2021 Version","author":"The Japan Society of Hepatology","year":"2021"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1177\/00031348211048838"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2011.06.017"}],"container-title":["Annals of Gastroenterological Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ags3.70048","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T07:44:18Z","timestamp":1762328658000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ags3.70048"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,31]]},"references-count":32,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1002\/ags3.70048"],"URL":"https:\/\/doi.org\/10.1002\/ags3.70048","archive":["Portico"],"relation":{},"ISSN":["2475-0328","2475-0328"],"issn-type":[{"value":"2475-0328","type":"print"},{"value":"2475-0328","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,31]]},"assertion":[{"value":"2025-03-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-31","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}