{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T00:22:07Z","timestamp":1792196527274,"version":"4.4.0"},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T00:00:00Z","timestamp":1756944000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T00:00:00Z","timestamp":1756944000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Annals of Gastroent Surgery"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Acute appendicitis in pregnant women requires accurate diagnosis and treatment because of potential pregnancy complications. Laparoscopic appendectomy (LA) has been associated with higher rates of fetal loss than open appendectomy (OA). Therefore, we conducted the first multicenter collaborative analysis in Japan to evaluate the safety and efficacy of LA during pregnancy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We retrospectively reviewed 152 pregnant women who underwent appendectomy for acute appendicitis between 2012 and 2021 using data from the Japan Society of Laparoscopic Colorectal Surgery. The patients were divided into the OA (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200992) and LA (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200960) groups. The primary endpoint was fetal loss during hospitalization. Patient demographics, perioperative outcomes, pathology, and pregnancy outcomes were analyzed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      No fetal loss occurred in either group. The operative time (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.485) and postoperative complications (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.708) were similar between the groups. However, the hospital stay was significantly shorter in the LA group than in the OA group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.037). The OA group had a higher rate of gangrenous or perforated appendicitis (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.017).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>LA is a safe alternative to OA in pregnant women, with no additional maternal complications and comparable fetal outcomes. LA does not negatively affect fetal health.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ags3.70089","type":"journal-article","created":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T01:25:02Z","timestamp":1757035502000},"page":"275-280","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A Multicenter Collaborative Study on the Safety and Efficacy of Laparoscopic Appendectomy During Pregnancy"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-1811-8793","authenticated-orcid":false,"given":"Katsuhiro","family":"Ogawa","sequence":"first","affiliation":[{"name":"Department of Gastroenterological and Pediatric Surgery Oita University Faculty of Medicine  Oita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0722-0343","authenticated-orcid":false,"given":"Tomonori","family":"Akagi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological and Pediatric Surgery Oita University Faculty of Medicine  Oita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2800-8314","authenticated-orcid":false,"given":"Hidefumi","family":"Shiroshita","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological and Pediatric Surgery Oita University Faculty of Medicine  Oita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal and Hepato\u2010Biliary\u2010Pancreatic Surgery Nippon Medical School, Graduate School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masashi","family":"Miguchi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery Hiroshima Prefectural Hospital  Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Eto","sequence":"additional","affiliation":[{"name":"Department of Surgery The Jikei University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuji","family":"Ohyama","sequence":"additional","affiliation":[{"name":"Biostatistics Center Kurume University  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiyoshi","family":"Kanazawa","sequence":"additional","affiliation":[{"name":"Department of Surgery Shimane Prefectural Central Hospital  Izumo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiji","family":"Matsuda","sequence":"additional","affiliation":[{"name":"The Fraternity Memorial Hospital Department of Surgery  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7210-7075","authenticated-orcid":false,"given":"Koya","family":"Hida","sequence":"additional","affiliation":[{"name":"Department of Surgery, Graduate School of Medicine Kyoto University  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9879-1239","authenticated-orcid":false,"given":"Seiichiro","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery Tokai University School of Medicine  Isehara Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4169-6334","authenticated-orcid":false,"given":"Takeshi","family":"Naitoh","sequence":"additional","affiliation":[{"name":"Department of Lower Gastrointestinal Surgery Kitasato University School of Medicine  Sagamihara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masafumi","family":"Inomata","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological and Pediatric Surgery Oita University Faculty of Medicine  Oita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Japan Society of Laparoscopic Colorectal Surgery","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,4]]},"reference":[{"issue":"3","key":"e_1_2_11_2_1","first-page":"384","article-title":"Laparoscopic Appendicectomy in All Trimesters of Pregnancy","volume":"13","author":"Machado N. O.","year":"2009","journal-title":"Journal of the Society of Laparoscopic & Robotic Surgeons"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2007.05.025"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.8889"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fsurg.2021.720351"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-014-3810-5"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(99)00244-5"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-011-1927-3"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2008.01.006"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6109(05)70215-2"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(97)70163-7"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/wjs.12422"},{"issue":"3","key":"e_1_2_11_13_1","first-page":"226","article-title":"Comparison of Laparoscopic and Open Appendectomy in Pregnancy: A Single Center Experience","volume":"25","author":"Kaplan M.","year":"2019","journal-title":"Ulus Travma Acil Cerrahi Dergisi = Turkish Journal of Trauma & Emergency Surgery"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2009.09.022"},{"issue":"3","key":"e_1_2_11_15_1","first-page":"321","article-title":"Laparoscopic Appendectomy in Pregnancy: A Case Series of Seven Patients","volume":"10","author":"Palanivelu C.","year":"2006","journal-title":"Journal of the Society of Laparoscopic & Robotic Surgeons"},{"key":"e_1_2_11_16_1","volume-title":"Guidelines for Diagnosis, Treatment, and Use of Laparoscopy for Surgical Problems During Pregnancy","author":"Society of American G, Endoscopic S","year":"2011"}],"container-title":["Annals of Gastroenterological Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ags3.70089","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ags3.70089","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ags3.70089","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T08:16:20Z","timestamp":1768464980000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ags3.70089"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,4]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1002\/ags3.70089"],"URL":"https:\/\/doi.org\/10.1002\/ags3.70089","archive":["Portico"],"relation":{},"ISSN":["2475-0328","2475-0328"],"issn-type":[{"value":"2475-0328","type":"print"},{"value":"2475-0328","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,4]]},"assertion":[{"value":"2025-07-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}