{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T17:23:36Z","timestamp":1785000216076,"version":"3.55.0"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T00:00:00Z","timestamp":1761436800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T00:00:00Z","timestamp":1761436800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Annals of Gastroent Surgery"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Perineal wound infection (PWI) is a critical complication unique to abdominoperineal resection (APR) that requires preventive interventions. This study compared the efficacy of a 4\u2010day regimen of sulbactam\/ampicillin (SBT\/ABPC) with that of a 1\u2010day regimen of cefmetazole (CMZ) for preventing PWI after APR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Eighty patients who underwent APR for rectal cancer were enrolled in this multicenter, open\u2010label, randomized controlled trial. The primary outcome was the incidence of PWI, and secondary outcomes included the incidence of surgical site infections (SSI), other complications, and length of postoperative hospital stay. Based on an assumed PWI incidence of 46% for CMZ and 14% for SBT\/ABPC, a sample size of 40 participants per group was required to achieve a 90% power at a two\u2010sided 10% significance level.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of the 80 randomized patients, 76 were analyzed in the SBT\/ABPC (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200939) and CMZ (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200937) groups. The incidence of PWI (10.3% vs. 24.3%, respectively;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.096) was significantly lower in the SBT\/ABPC group than in the CMZ group, based on a planned two\u2010sided significance level of 10%. SSI, other complications, including antibiotic\u2010related adverse events, and length of postoperative hospital stay, were not significantly different between the two groups. SBT\/ABPC demonstrated broader bacterial coverage than CMZ in the PWI treatment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The 4\u2010day SBT\/ABPC regimen significantly reduced the incidence of PWI after APR compared to the 1\u2010day CMZ regimen. This simple approach to antibiotic selection may be beneficial for preventing PWI.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ags3.70118","type":"journal-article","created":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T06:03:02Z","timestamp":1761544982000},"page":"15-24","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Comparing Prophylactic Administration of Sulbactam\/Ampicillin Versus Cefmetazole for Prevention of Perineal Wound Infection Following Abdominoperineal Resection for Rectal Cancer: A Multicenter Randomized Controlled Trial"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9947-9458","authenticated-orcid":false,"given":"Akitoshi","family":"Nankaku","sequence":"first","affiliation":[{"name":"Department of Gastrointestinal Surgery, Graduate School of Medicine Institute of Science Tokyo  Bunkyo\u2010ku Tokyo Japan"},{"name":"Division of Colon and Rectal Surgery Shizuoka Cancer Center Hospital  Sunto\u2010gun Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2497-5633","authenticated-orcid":false,"given":"Shunsuke","family":"Kasai","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery, Graduate School of Medicine Institute of Science Tokyo  Bunkyo\u2010ku Tokyo Japan"},{"name":"Division of Colon and Rectal Surgery Shizuoka Cancer Center Hospital  Sunto\u2010gun Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5657-8686","authenticated-orcid":false,"given":"Akio","family":"Shiomi","sequence":"additional","affiliation":[{"name":"Division of Colon and Rectal Surgery Shizuoka Cancer Center Hospital  Sunto\u2010gun Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taiki","family":"Masuda","sequence":"additional","affiliation":[{"name":"Division of Surgery Musashino Red Cross Hospital  Musashino Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Hazama","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery Shizuoka General Hospital  Aoiku Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriko","family":"Iwata","sequence":"additional","affiliation":[{"name":"Division of Surgery Edogawa Hospital  Edogawaku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunichiro","family":"Kato","sequence":"additional","affiliation":[{"name":"Division of Digestive Surgery Tsuchiura Kyodo General Hospital  Tsuchiura Ibaraki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2360-5323","authenticated-orcid":false,"given":"Shinichi","family":"Yamauchi","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery, Graduate School of Medicine Institute of Science Tokyo  Bunkyo\u2010ku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Clinical Biostatistics, Graduate School of Medical and Dental Sciences Institute of Science Tokyo  Bunkyo\u2010ku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiro","family":"Hirakawa","sequence":"additional","affiliation":[{"name":"Department of Clinical Biostatistics, Graduate School of Medical and Dental Sciences Institute of Science Tokyo  Bunkyo\u2010ku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyasu","family":"Kagawa","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery, Graduate School of Medicine Institute of Science Tokyo  Bunkyo\u2010ku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3183-349X","authenticated-orcid":false,"given":"Masanori","family":"Tokunaga","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery, Graduate School of Medicine Institute of Science Tokyo  Bunkyo\u2010ku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7885-2276","authenticated-orcid":false,"given":"Yusuke","family":"Kinugasa","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery, Graduate School of Medicine Institute of Science Tokyo  Bunkyo\u2010ku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,26]]},"reference":[{"issue":"5","key":"e_1_2_10_2_1","first-page":"388","article-title":"Morbidity and Mortality Following Abdominoperineal Resection for Low Rectal Adenocarcinoma","volume":"53","author":"Luna P\u00e9rez P.","year":"2001","journal-title":"Revista de Investigacion Clinica; 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