{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T14:08:57Z","timestamp":1784297337418,"version":"3.55.0"},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T00:00:00Z","timestamp":1763683200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T00:00:00Z","timestamp":1763683200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Annals of Gastroent Surgery"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Spigelman stage IV duodenal polyposis (SP\u2010stage IV DP) is associated with high duodenal cancer risk in patients with familial adenomatous polyposis (FAP). This study evaluated the surgical and oncological outcomes of pancreas\u2010sparing total duodenectomy (PSTD) as a surgical prophylaxis for severe duodenal polyposis in FAP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Medical records were reviewed to evaluate factors concerning short\u2010 and long\u2010term clinical and oncological outcomes in consecutive patients with FAP who underwent PSTD for SP\u2010stage IV DP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      There were twenty\u2010seven patients (median age: 48\u2009years) from 26 families, of whom 12 were female. Clavien\u2013Dindo grade IIIa\/IIIb complications included delayed gastric emptying (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200914) and pancreatic fistula (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200910); no mortalities were observed. Histopathological examinations revealed no malignant neoplasms deeper than T1a in the duodenum and ampulla. Follow\u2010up (median 6.4\u2009years) revealed anastomotic stricture of the reconstructed neo\u2010common channel (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20095), anastomotic ulcer of the gastrojejunostomy site (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20095), acute pancreatitis (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20094), and acute cholangitis (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20092), all of which were successfully treated endoscopically or conservatively. Malignant neoplasms after PSTD included gastric cancer (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20093), remnant ano\u2010rectal cancer (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20093), ileal cancer (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20091), ileal pouch cancer (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20091), and endometrial cancer (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20091). The cumulative 10\u2010year survival rate following PSTD was 87.4%.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>PSTD for the prophylactic management of SP\u2010stage IV DP was associated with notable but manageable postoperative morbidity. Long\u2010term surveillance remains essential for the development of extraduodenal malignancies to confirm the oncological efficacy of this type of surgery.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ags3.70125","type":"journal-article","created":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T09:12:06Z","timestamp":1763716326000},"page":"534-542","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Outcomes of Pancreas\u2010Sparing Total Duodenectomy for Severe Duodenal Polyposis in Patients With Familial Adenomatous Polyposis"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9150-2679","authenticated-orcid":false,"given":"Takehiro","family":"Shiraishi","sequence":"first","affiliation":[{"name":"Department of Digestive Tract and General Surgery, Saitama Medical Center Saitama Medical University  Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideyuki","family":"Ishida","sequence":"additional","affiliation":[{"name":"Department of Digestive Tract and General Surgery, Saitama Medical Center Saitama Medical University  Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5937-2285","authenticated-orcid":false,"given":"Takatoshi","family":"Matsuyama","sequence":"additional","affiliation":[{"name":"Department of Digestive Tract and General Surgery, Saitama Medical Center Saitama Medical University  Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6566-6714","authenticated-orcid":false,"given":"Noriyasu","family":"Chika","sequence":"additional","affiliation":[{"name":"Department of Digestive Tract and General Surgery, Saitama Medical Center Saitama Medical University  Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4948-8142","authenticated-orcid":false,"given":"Yoshiko","family":"Mori","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics, Saitama Medical Center Saitama Medical University  Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norimichi","family":"Chiyonobu","sequence":"additional","affiliation":[{"name":"Department of Digestive Tract and General Surgery, Saitama Medical Center Saitama Medical University  Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9895-8820","authenticated-orcid":false,"given":"Youichi","family":"Kumagai","sequence":"additional","affiliation":[{"name":"Department of Digestive Tract and General Surgery, Saitama Medical Center Saitama Medical University  Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5959-8911","authenticated-orcid":false,"given":"Ibuki","family":"Fujinuma","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery Saitama Cancer Center  Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiro","family":"Ogura","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery Saitama Cancer Center  Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,21]]},"reference":[{"key":"e_1_2_11_2_1","volume-title":"Familial Polyposis Coli: Family Studies, Histopathology, Differential Diagnosis, and Results of Treatment","author":"Bussey H. 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