{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T18:44:07Z","timestamp":1788288247185,"version":"build-2803163510"},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T00:00:00Z","timestamp":1764028800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T00:00:00Z","timestamp":1764028800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Annals of Gastroent Surgery"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Hepatocellular carcinoma (HCC) is a leading cause of cancer mortality, with post\u2010hepatectomy liver failure (PHLF) representing a major complication. We aimed to develop an objective, multidimensional liver function grading system via latent class analysis (LCA) and assess its predictive value for PHLF in combination with surgical parameters.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Among 185 HCC patients who underwent resection, the LCA incorporated nine liver function indicators, including severity of liver cirrhosis, splenomegaly, platelet count (PLT), etc., to categorize liver function into three grades: poor, intermediate, and good. Discrimination was evaluated using entropy. Restricted cubic spline analysis assessed the association between blood loss and PHLF, and multivariate logistic regression identified independent predictors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      LCA yielded three distinct classes (entropy\u2009=\u20090.953). Blood loss showed a nonlinear relationship with PHLF (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.012), with a risk threshold at 150\u2009mL. PHLF incidence was 36.6% in poor versus 11.5% in good liver function. Liver function grade and resection extent independently predicted PHLF, with consistent effects across resection subgroups (interaction\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This LCA\u2010based grading system, integrating imaging and biochemical markers, enables precise PHLF risk stratification and, combined with surgical variables, may inform individualized perioperative management in HCC resection.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ags3.70138","type":"journal-article","created":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T16:45:16Z","timestamp":1764089116000},"page":"819-826","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Association Between Liver Function Grade and Post\u2010Hepatectomy Liver Failure in Patients With Hepatocellular Carcinoma: A Latent Class Analysis"],"prefix":"10.1002","volume":"10","author":[{"given":"Ling","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Hepatobiliary and Pancreatic Surgery Hangzhou First People's Hospital Affiliated to Medical School of Westlake University  Hangzhou Zhejiang China"},{"name":"Department of Hepatobiliary and Pancreatic Surgery The Fourth School of Clinical Medicine, Zhejiang Chinese Medical University  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jintao","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary and Pancreatic Surgery The Fourth School of Clinical Medicine, Zhejiang Chinese Medical University  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary and Pancreatic Surgery The Fourth School of Clinical Medicine, Zhejiang Chinese Medical University  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenao","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery Hangzhou First People's Hospital Affiliated to Medical School of Westlake University  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiachen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary and Pancreatic Surgery The Fourth School of Clinical Medicine, Zhejiang Chinese Medical University  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3599-1337","authenticated-orcid":false,"given":"Changku","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary and Pancreatic Surgery The Fourth School of Clinical Medicine, Zhejiang Chinese Medical University  Hangzhou Zhejiang China"},{"name":"Department of Hepatobiliary and Pancreatic Surgery The Second Affiliated Hospital, School of Medicine, Zhejiang University  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,25]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)30010-2"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2021.05.045"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.21037\/hbsn-22-410"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/bjs\/znac017"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/ti.2023.11176"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diii.2017.10.008"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aohep.2021.100535"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e3182724ce8"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/JS9.0000000000001156"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v27.i5.416"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202205-0913OC"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphys.2016.05.018"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v19.i38.6329"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-023-05834-2"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ags3.12692"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/bjs\/znad233"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2014.06.012"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.13799"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2017-314641"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2021.05.026"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-020-07313-7"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2019.04.006"}],"container-title":["Annals of Gastroenterological Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ags3.70138","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ags3.70138","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ags3.70138","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T14:03:42Z","timestamp":1778853822000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ags3.70138"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,25]]},"references-count":22,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1002\/ags3.70138"],"URL":"https:\/\/doi.org\/10.1002\/ags3.70138","archive":["Portico"],"relation":{},"ISSN":["2475-0328","2475-0328"],"issn-type":[{"value":"2475-0328","type":"print"},{"value":"2475-0328","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,25]]},"assertion":[{"value":"2025-08-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}