{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T14:14:59Z","timestamp":1778854499214,"version":"3.51.4"},"reference-count":15,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T00:00:00Z","timestamp":1766707200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T00:00:00Z","timestamp":1766707200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP\u201023K08133"],"award-info":[{"award-number":["JP\u201023K08133"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Annals of Gastroent Surgery"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The role of anatomical resection (AR) in hepatocellular carcinoma (HCC) remains controversial, particularly for tumors \u2264\u20095\u2009cm without vascular invasion. We aimed to evaluate the long\u2010term outcomes of AR versus non\u2010anatomical resection (NAR) in solitary HCC presumed negative for microvascular invasion (MVI) and intrahepatic metastasis (IM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We retrospectively analyzed 303 patients with solitary HCC who underwent hepatectomy between 2002 and 2019. Predictive factors for MVI and IM were identified, and 214 patients with solitary HCC \u2264\u20095\u2009cm and predicted absence of MVI and IM were further analyzed. We compared the perioperative and oncological outcomes between the AR (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200994) and NAR (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009120) groups. Subsequently, we conducted propensity score matching (\n                      <jats:italic>n\u2009=<\/jats:italic>\n                      \u200941 per group) and performed subgroup analyses based on tumor size.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Des\u2010\u03b3\u2010carboxy prothrombin &gt;\u2009150 mAU\/mL was identified as an independent predictor for MVI and IM. Compared with the NAR group, the AR group had a significantly longer operative time, greater blood loss, and higher rate of complications, but showed no significant differences in recurrence\u2010free survival and overall survival. Recurrence\u2010free survival and overall survival remained comparable between the two groups after propensity score matching. Subgroup analyses by tumor size (0\u20132.0 and 2.1\u20135.0\u2009cm) showed no prognostic advantage for AR over NAR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>For solitary HCC \u2264\u20095\u2009cm without predicted MVI and IM, NAR and AR result in comparable long\u2010term outcomes. The resection strategy should prioritize remnant liver function over anatomical extent.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ags3.70157","type":"journal-article","created":{"date-parts":[[2025,12,27]],"date-time":"2025-12-27T05:50:27Z","timestamp":1766814627000},"page":"861-870","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparison of Anatomical and Non\u2010Anatomical Resection in Low Microvascular Invasion Risk Solitary Hepatocellular Carcinoma \u2264\u20095\u2009cm"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8589-0038","authenticated-orcid":false,"given":"Norifumi","family":"Iseda","sequence":"first","affiliation":[{"name":"Department of Surgery and Science, Graduate School of Medical Sciences Kyushu University  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0382-2520","authenticated-orcid":false,"given":"Shinji","family":"Itoh","sequence":"additional","affiliation":[{"name":"Department of Surgery and Science, Graduate School of Medical Sciences Kyushu University  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3776-7913","authenticated-orcid":false,"given":"Kyohei","family":"Yugawa","sequence":"additional","affiliation":[{"name":"Department of Surgery and Science, Graduate School of Medical Sciences Kyushu University  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4642-5058","authenticated-orcid":false,"given":"Shohei","family":"Yoshiya","sequence":"additional","affiliation":[{"name":"Department of Surgery and Science, Graduate School of Medical Sciences Kyushu University  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-0417-9137","authenticated-orcid":false,"given":"Takashi","family":"Motomura","sequence":"additional","affiliation":[{"name":"Department of Surgery and Science, Graduate School of Medical Sciences Kyushu University  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4019-8288","authenticated-orcid":false,"given":"Takeo","family":"Toshima","sequence":"additional","affiliation":[{"name":"Department of Surgery and Science, Graduate School of Medical Sciences Kyushu University  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4497-1816","authenticated-orcid":false,"given":"Tomoharu","family":"Yoshizumi","sequence":"additional","affiliation":[{"name":"Department of Surgery and Science, Graduate School of Medical Sciences Kyushu University  Fukuoka 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