{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T14:15:02Z","timestamp":1778854502556,"version":"3.51.4"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T00:00:00Z","timestamp":1766966400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T00:00:00Z","timestamp":1766966400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Annals of Gastroent Surgery"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Increase in surgical patients undergoing antithrombotic therapy (ATT) has intensified the concerns regarding perioperative bleeding and thromboembolic complications. This study evaluated the safety of hepatectomy in patients receiving ATT, with a focus on those receiving dual therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively analyzed 749 patients who underwent elective hepatectomies between 2011 and 2024. Among them, 140 received ATT according to the Japanese guidelines, and 98 were matched 1:1 with non\u2010ATT controls using propensity scores. The primary outcome was major morbidity, defined as Clavien\u2013Dindo \u2265grade III; intraoperative blood loss and transfusion requirement were secondary outcomes. Outcomes were also compared across the ATT regimens, including dual therapy (antiplatelet plus anticoagulants).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Compared with the non\u2010ATT group, the ATT group had a significantly longer operative time (median, 318 vs. 250\u2009min;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.019), while blood loss (355 vs. 300\u2009mL;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.460), transfusion rate (19.4% vs. 23.5%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.602), and severe complication rate (32.7% vs. 22.4%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.150) were not significantly different. Post\u2010hepatectomy liver failure (PHLF) incidence (16.3% vs. 13.3%) and median hospital stay (13 vs. 12\u2009days) were also comparable. In subgroup analysis, patients receiving dual therapy exhibited higher complication rates, including hemorrhagic events (30%), Clavien\u2013Dindo\u2265grade III (40%), and PHLF (50%), exceeding the rates seen in monotherapy groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Hepatectomies can be safely performed in patients receiving well\u2010managed ATT. However, dual therapy was associated with higher rates of perioperative complications, including bleeding and PHLF, compared with monotherapy or no ATT, underscoring the need for heightened caution and individualized management in this high\u2010risk group.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ags3.70160","type":"journal-article","created":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T01:11:21Z","timestamp":1767057081000},"page":"883-892","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Elevated Risk of Complications in Patients Receiving Dual Antithrombotic Therapy Undergoing Hepatectomy: A Single\u2010Center Audit of 749 Cases"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9143-256X","authenticated-orcid":false,"given":"Haruki","family":"Mori","sequence":"first","affiliation":[{"name":"Department of Surgery Shiga University of Medical Science  Otsu Shiga Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiromitsu","family":"Maehira","sequence":"additional","affiliation":[{"name":"Department of Surgery Shiga University of Medical Science  Otsu Shiga Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuhito","family":"Nitta","sequence":"additional","affiliation":[{"name":"Department of Surgery Shiga University of Medical Science  Otsu Shiga Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-9892-0041","authenticated-orcid":false,"given":"Takeru","family":"Maekawa","sequence":"additional","affiliation":[{"name":"Department of Surgery Shiga University of Medical Science  Otsu Shiga Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toru","family":"Miyake","sequence":"additional","affiliation":[{"name":"Department of Surgery Shiga University of Medical Science  Otsu Shiga Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1279-5942","authenticated-orcid":false,"given":"Sachiko","family":"Kaida","sequence":"additional","affiliation":[{"name":"Department of Surgery Shiga University of Medical Science  Otsu Shiga Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masatsugu","family":"Kojima","sequence":"additional","affiliation":[{"name":"Department of Surgery Shiga University of Medical Science  Otsu Shiga Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7344-2892","authenticated-orcid":false,"given":"Katsushi","family":"Takebayashi","sequence":"additional","affiliation":[{"name":"Department of Surgery Shiga University of Medical Science  Otsu Shiga Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Sonoda","sequence":"additional","affiliation":[{"name":"Department of Surgery Shiga University of 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