{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T11:15:34Z","timestamp":1788434134065,"version":"build-2803163510"},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T00:00:00Z","timestamp":1769990400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T00:00:00Z","timestamp":1769990400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Annals of Gastroent Surgery"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Radical gastrectomy, followed by adjuvant chemotherapy has been a common practice in Japan for peritoneal lavage cytology\u2010positive (CY1) but peritoneal dissemination\u2010negative (P0) stage IV gastric cancer. This study aimed to clarify the differences in treatment outcomes between upfront surgery and preoperative chemotherapy, followed by surgery for patients with CY1P0 gastric cancer using data from Japanese patients recruited for the CONVO\u2010GC\u20101 study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study used data from Japanese patients with CY1P0 gastric cancer recruited for the international retrospective observational CONVO\u2010GC\u20101 study. Gastrectomy was performed between January 1, 2001, and December 31, 2014. CY1 was cytologically confirmed. The patients were divided into two groups: upfront surgery (Sx) and preoperative chemotherapy, followed by surgery (CSx). Patient background and survival outcomes were compared between the groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Four hundred and thirty\u2010three patients treated at 45 Japanese institutions were analyzed. There were 306 and 127 patients in the Sx and CSx groups, respectively. The 5\u2010year overall survival (OS) rates were 19.2% in the Sx group and 35.9% in the CSx group, with a significant difference. When stratifying OS of the two groups by residual tumor status, the 5\u2010year OS rates were 43.0% in the CSx\u2010R0 group, 14.9% in the CSx\u2010R1 group, 20.7% in the Sx\u2010R1 group, and 0.0% in the CSx\u2010R2 and Sx\u2010R2 groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In CY1P0 gastric cancer, survival was better with preoperative chemotherapy, followed by surgery than with upfront surgery. Survival was particularly favorable in patients who underwent R0 resection.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ags3.70188","type":"journal-article","created":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T23:24:48Z","timestamp":1770074688000},"page":"1021-1030","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparison Between Upfront Surgery and Preoperative Chemotherapy for\n                    <scp>CY1P0<\/scp>\n                    Gastric Cancer: A Japanese Sub\u2010Analysis of\n                    <scp>CONVO<\/scp>\n                    \u2010\n                    <scp>GC<\/scp>\n                    \u20101"],"prefix":"10.1002","volume":"10","author":[{"given":"Kenichiro","family":"Furukawa","sequence":"first","affiliation":[{"name":"Division of Gastric Surgery Shizuoka Cancer Center  Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5245-7502","authenticated-orcid":false,"given":"Itaru","family":"Yasufuku","sequence":"additional","affiliation":[{"name":"Department of Clinical Anatomy Development Studies Gifu University Graduate School of Medicine  Gifu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hironori","family":"Ishigami","sequence":"additional","affiliation":[{"name":"Department of Chemotherapy The University of Tokyo Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Yura","sequence":"additional","affiliation":[{"name":"Department of Gastric Surgery National Cancer Center Hospital East  Kashiwa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3564-6891","authenticated-orcid":false,"given":"Takanobu","family":"Yamada","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery Kanagawa Cancer Center  Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeaki","family":"Baba","sequence":"additional","affiliation":[{"name":"Department of Surgery, School of Medicine Iwate Medical University  Iwate Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2246-3028","authenticated-orcid":false,"given":"Takeshi","family":"Kubota","sequence":"additional","affiliation":[{"name":"Division of Digestive Surgery, Department of Surgery Kyoto Prefectural University of Medicine  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erina","family":"Nagai","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery Shizuoka General Hospital  Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seito","family":"Fujibayashi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological and Pediatric Surgery Gifu University Graduate School of Medicine  Gifu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9238-2437","authenticated-orcid":false,"given":"Mitsumasa","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Gastric Surgery National Cancer Center Hospital East  Kashiwa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7365-8733","authenticated-orcid":false,"given":"Takahiro","family":"Kinoshita","sequence":"additional","affiliation":[{"name":"Department of Gastric Surgery National Cancer Center Hospital East  Kashiwa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuhisa","family":"Matsuhashi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological and Pediatric Surgery Gifu University Graduate School of Medicine  Gifu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2967-8267","authenticated-orcid":false,"given":"Masanori","family":"Terashima","sequence":"additional","affiliation":[{"name":"Division of Gastric Surgery Shizuoka Cancer Center  Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,2]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"World Health Organization \u201cCancer Today \u201dhttps:\/\/gco.iarc.fr\/today\/home."},{"key":"e_1_2_11_3_1","volume-title":"TNM Classififcation of Malignant Tumours (UICC), 9th Edition","author":"Brierley J. 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