{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T11:15:25Z","timestamp":1788434125935,"version":"build-2803163510"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T00:00:00Z","timestamp":1770163200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T00:00:00Z","timestamp":1770163200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["24K11898"],"award-info":[{"award-number":["24K11898"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["24K11920"],"award-info":[{"award-number":["24K11920"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP22K16453"],"award-info":[{"award-number":["JP22K16453"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Annals of Gastroent Surgery"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The prognostic impact of prior cholecystectomy (CCY) in patients with colorectal cancer (CRC) remains uncertain. The aim of this study was to evaluate the prognostic impact of prior CCY in a large cohort of patients with CRC, with particular attention to tumor location.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively analyzed all patients diagnosed with colorectal adenocarcinoma between January 2012 and December 2023. Patients were classified into proximal (cecum, ascending, and transverse) and distal (descending, sigmoid, and rectum) groups. Survival outcomes were compared using multivariate Cox proportional hazards regression models, including an interaction term between tumor location and history of CCY. Propensity score matching (PSM) was performed as a sensitivity analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 3487 patients (1375 proximal and 2112 distal CRC), 158 (4.8%) had a history of CCY. Proximal CRC was more frequently associated with female sex, older age, history of CCY, poor differentiation, BRAF mutation, MSI\u2010high status, and non\u2010resection initial strategy (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009\u2264\u20090.005). Among proximal CRC patients, multivariate analysis revealed TNM stage III\/IV (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), non\u2010resection initial strategy (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), and history of CCY (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.042) were independent predictors of poor overall survival (OS). Prior CCY was associated with worse OS in proximal CRC (\n                      <jats:italic>p\u2009=<\/jats:italic>\n                      \u20090.004). A significant interaction between tumor location and history of CCY was observed (\n                      <jats:italic>p<\/jats:italic>\n                      for interaction\u2009=\u20090.025).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>History of CCY was associated with worse prognosis in proximal CRC but not in distal CRC, suggesting a differential impact of CCY on prognosis in CRC. Our findings would provide insight into further research on bile acid metabolism or microbiome modulation in CRC patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ags3.70190","type":"journal-article","created":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T23:05:07Z","timestamp":1770246307000},"page":"1201-1208","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Differential Prognostic Impact of Prior Cholecystectomy Between Proximal and Distal Colorectal Cancer: A 12\u2010Year Retrospective Cohort Study of 3487 Consecutive Patients"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6953-1801","authenticated-orcid":false,"given":"Masashi","family":"Tsunematsu","sequence":"first","affiliation":[{"name":"Department of Digestive Surgery Saku Central Hospital Advanced Care Center  Saku Nagano Japan"},{"name":"Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery The Jikei University School of Medicine  Minato\u2010ku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1686-3228","authenticated-orcid":false,"given":"Koichiro","family":"Haruki","sequence":"additional","affiliation":[{"name":"Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery The Jikei University School of Medicine  Minato\u2010ku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiro","family":"Yanamoto","sequence":"additional","affiliation":[{"name":"Department of Digestive Surgery Saku Central Hospital Advanced Care Center  Saku Nagano Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-9831-9091","authenticated-orcid":false,"given":"Takuo","family":"Takehana","sequence":"additional","affiliation":[{"name":"Department of Digestive Surgery Saku Central Hospital Advanced Care Center  Saku Nagano 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