{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T11:15:24Z","timestamp":1788434124805,"version":"build-2803163510"},"reference-count":36,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T00:00:00Z","timestamp":1773100800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T00:00:00Z","timestamp":1773100800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Annals of Gastroent Surgery"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>As the aging of the global population increases, the number of elderly patients with colorectal liver metastasis (CRLM) is expected to increase. The aim of this study was to clarify the long\u2010term oncological outcomes and treatment of CRLM in elderly patients aged \u2265\u200980.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Patients with CRLM were identified from the Japanese database of Liver Metastases Survey of Colorectal Cancer, collected from 145 centers. Two thousand four hundred nine patients with liver resection were eligible for analysis. This cohort was divided into two groups aged &lt;\u200980 (group Y (younger);\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20092194) and \u2265\u200980 (group E (elderly);\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009215). We compared the long\u2010term outcomes after liver resection of patients with CRLM aged \u2265\u200980 and\u2009&lt;\u200980\u2009years after adjustment using propensity score matching (PSM), and we identified the reasons for differences in these outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      After PSM, group E showed a comparable recurrence\u2010free survival to that in group Y (hazard ratio (HR): 1.20,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.16). However, group E had significantly worse cancer\u2010specific survival (CSS) (HR: 1.77,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002) and overall survival (OS) (HR: 1.80,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0004). Treatment for recurrence was given at a significantly lower rate in group E (80\/130 (61.5%) vs. 1148\/1329 (86.4%),\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Surgical resection seems to be as effective in elderly patients aged \u2265\u200980 as in nonelderly patients. The significantly worse CSS and OS may have resulted from a lower rate of treatment for recurrence in elderly patients aged \u2265\u200980. Physicians should keep this finding in mind with regard to limitations of treatments for recurrence after initial liver resection in elderly patients aged \u2265\u200980 with CRLM.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ags3.70213","type":"journal-article","created":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T07:50:19Z","timestamp":1773129019000},"page":"1107-1119","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Surgical Resection for Colorectal Liver Metastasis in Elderly Patients Aged \u2265\u200980: A Retrospective Nationwide Cohort Survey in Japan With Propensity Score Matching"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1210-2920","authenticated-orcid":false,"given":"Kiichi","family":"Sugimoto","sequence":"first","affiliation":[{"name":"Department of Coloproctological Surgery Juntendo University Faculty of Medicine  Tokyo 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Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5881-0036","authenticated-orcid":false,"given":"Kazushige","family":"Kawai","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyoshi","family":"Hasegawa","sequence":"additional","affiliation":[{"name":"Hepato\u2010Biliary\u2010Pancreatic Surgery Division, Department of Surgery, Graduate School of Medicine The University of Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiichi","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Surgery Tokyo Metropolitan Health and Hospitals Corporation Ohkubo Hospital  Tokyo 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