{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T11:14:55Z","timestamp":1788347695739,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:00:00Z","timestamp":1777507200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:00:00Z","timestamp":1777507200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Annals of Gastroent Surgery"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To explore the therapeutic impact of D3 lymph node dissection for non\u2010metastatic colon cancers, evaluating the therapeutic value index for each lymph node station according to surgical stages.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Consecutive patients with surgical Stage I\u2013III colon and rectosigmoid cancer who underwent curative resection between January 2003 and December 2014 were identified from the Japanese Society for Cancer of the Colon and Rectum database and analyzed. The therapeutic value index (TVI) was defined as the incidence of lymph node metastasis times 5\u2010year overall survival and calculated for each nodal station stratified by tumor stages.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 21\u2009914 patients, including 9583 patients with right\u2010sided colon cancer and 12\u2009331 with left\u2010sided colon cancer, were eligible for analysis. In right\u2010sided colon cancer, reflecting differences in tumor location and the presence of the right colic artery, variability in the TVIs was observed among stations #203 to #223. When the three stations were collectively considered as a single group of main lymph nodes, the combined TVIs for sT1Nany, sT2N0, sT2Nany, sT3\u20104\u2009N0, and sT3\u20104Nany were 0.630, 0.493, 0.857, 0.849, and 2.274, respectively. For station #253 in left\u2010sided colon cancers, the TVIs for sT1Nany, sT2N0, sT2Nany, sT3\u20104\u2009N0, and sT3\u20104Nany were 0.120, 0.278, 0.634, 0.475, and 1.234, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Within a D3\u2010treated cohort stratified by surgical stage, the TVI of the main lymph nodes for sT2N0 tumors remained low, approximating that of sT1Nany rather than sT2Nany or sT3\u20104 tumors. Further evaluation of the therapeutic impact of D3 lymphadenectomy for clinically node\u2010negative T2 colon cancer is warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ags3.70223","type":"journal-article","created":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T09:31:34Z","timestamp":1777541494000},"page":"1527-1537","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Optimal Indication of\n                    <scp>D3<\/scp>\n                    Lymph Node Dissection for Non\u2010Metastatic Colon Cancers by Tumor Stages: Evaluation of Therapeutic Value Index for Each Lymph Node Station"],"prefix":"10.1002","volume":"10","author":[{"given":"Akira","family":"Ouchi","sequence":"first","affiliation":[{"name":"Department of Gastroenterological Surgery Aichi Cancer Center Hospital  Aichi 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