{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T11:14:39Z","timestamp":1788347679646,"version":"build-2803163510"},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,24]],"date-time":"2026-05-24T00:00:00Z","timestamp":1779580800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,24]],"date-time":"2026-05-24T00:00:00Z","timestamp":1779580800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Annals of Gastroent Surgery"],"published-print":{"date-parts":[[2026,9]]},"abstract":"ABSTRACT<\/jats:title>\n \n Objectives<\/jats:title>\n Microsatellite instability\u2010high (MSI\u2010H) or mismatch repair\u2010deficient (dMMR) colorectal cancer (CRC) is a distinct subtype. Although immune checkpoint inhibitors are used for advanced cases, data on its frequency and characteristics, especially in resectable Asian CRC, remain limited. This study investigated MSI\u2010H\/dMMR frequency and features in Japanese patients to support future personalized treatment strategies.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n This multicenter observational study included 1464 patients with pathologically confirmed primary CRC enrolled from April 2024 to March 2025 at 25 institutions affiliated with Osaka University. MSI\/MMR status and clinicopathological data were extracted from a prospectively maintained database. Univariate analyses were performed to evaluate factors associated with MSI\u2010H\/dMMR.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Among 1464 patients, 137 (9.4%) had MSI\u2010H\/dMMR tumors. MSI\/MMR testing was conducted preoperatively in 772 patients (52.7%). MSI\u2010H\/dMMR was more frequent in patients aged \u2265\u200970\u2009years, in females (OR\u2009=\u20091.46,\n p<\/jats:italic>\n \u2009=\u20090.036), and in tumors located in the cecum, ascending, or transverse colon (\n p<\/jats:italic>\n \u2009<\u20090.001). It was significantly less common in Stage IV disease (OR\u2009=\u20090.22,\n p<\/jats:italic>\n \u2009<\u20090.001) and\n KRAS<\/jats:italic>\n \u2010mutant tumors (OR\u2009=\u20090.22,\n p<\/jats:italic>\n \u2009<\u20090.001), but strongly associated with\n BRAF V600E<\/jats:italic>\n mutation (OR\u2009=\u200952.41,\n p<\/jats:italic>\n \u2009<\u20090.001), poorly differentiated adenocarcinoma (OR\u2009=\u20097.17,\n p<\/jats:italic>\n \u2009<\u20090.001), and mucinous adenocarcinoma (OR\u2009=\u20093.10,\n p<\/jats:italic>\n \u2009=\u20090.002).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n MSI\u2010H\/dMMR CRC accounted for 9.4% of Japanese patients, including resectable cases, and exhibited distinct clinical and molecular characteristics. These findings provide a basis for future personalized treatment strategies in this population.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/ags3.70226","type":"journal-article","created":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T06:32:37Z","timestamp":1779690757000},"page":"1538-1545","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prevalence of\n MSI<\/scp>\n \u2010H\/\n dMMR<\/scp>\n Colorectal Cancer in Japan: Data From the Clinical Study Group of the University of Osaka\u2010Colorectal Registry"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2687-9933","authenticated-orcid":false,"given":"Yoshihiro","family":"Morimoto","sequence":"first","affiliation":[{"name":"Department of Gastroenterological Surgery Osaka General Medical Center Osaka Japan"},{"name":"Clinical Study Group of the University of Osaka Osaka 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Japan"},{"name":"Department of Gastroenterological Surgery Osaka International Medical & Science Center, Osaka Keisatsu Hospital Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayuki","family":"Hiraki","sequence":"additional","affiliation":[{"name":"Clinical Study Group of the University of Osaka Osaka Japan"},{"name":"Department of Surgery Kansai Rosai Hospital Amagasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4567-3802","authenticated-orcid":false,"given":"Yozo","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Clinical Study Group of the University of Osaka Osaka Japan"},{"name":"Department of Surgery Toyonaka Municipal Hospital Toyonaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinichi","family":"Yoshioka","sequence":"additional","affiliation":[{"name":"Clinical Study Group of the University of Osaka Osaka Japan"},{"name":"Department of Surgery Yao Municipal Hospital Yao Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuyoshi","family":"Tei","sequence":"additional","affiliation":[{"name":"Clinical Study Group of the University of Osaka Osaka Japan"},{"name":"Department of Surgery Osaka Rosai Hospital Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu","family":"Okamura","sequence":"additional","affiliation":[{"name":"Clinical Study Group of the University of Osaka Osaka Japan"},{"name":"Department of Surgery Suita Municipal Hospital Suita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukako","family":"Mokutani","sequence":"additional","affiliation":[{"name":"Clinical Study Group of the University of Osaka Osaka Japan"},{"name":"Department of Gastroenterological Surgery Higashiosaka City Medical Center Higashiosaka 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