{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T11:14:29Z","timestamp":1788347669017,"version":"build-2803163510"},"reference-count":16,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T00:00:00Z","timestamp":1779667200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T00:00:00Z","timestamp":1779667200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Annals of Gastroent Surgery"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Surgical site infection (SSI) is a major complication after ileal pouch\u2013anal anastomosis (IPAA) in pediatric ulcerative colitis (UC), significantly impairing quality of life. The lymphocyte\u2010to\u2013C\u2010reactive protein ratio (LCR), a composite marker of systemic inflammation and immune\/nutritional status, has emerged as a potential predictor of postoperative outcomes. This study assessed the utility of preoperative LCR in predicting SSI in pediatric UC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively reviewed pediatric UC patients who underwent IPAA at Mie University Hospital between 2000 and 2024. Preoperative LCR values were analyzed, and the optimal cutoff for SSI prediction was determined using receiver operating characteristic (ROC) analysis. Multivariate logistic regression was performed to identify independent risk factors. SSI was defined according to CDC criteria within 30\u2009days postoperatively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 57 patients, 11 (19.3%) developed SSI. The incidence was higher in three\u2010stage procedures than in two\u2010stage procedures (22.7% vs. 17.1%). In both groups, preoperative LCR was significantly lower in SSI\u2010positive patients. ROC analysis demonstrated good discrimination (AUC: 0.80), with an optimal cutoff of LCR &lt;\u20095000 (sensitivity: 90.9%, specificity: 71.7%). Multivariate analysis confirmed LCR &lt;\u20095000 as an independent predictor of SSI (odds ratio [OR]: 6.34, 95% CI: 1.23\u201348.2,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.027).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Preoperative LCR is a simple, objective biomarker that reliably predicts SSI risk in pediatric UC patients undergoing IPAA. Incorporating LCR into preoperative risk stratification may enable personalized interventions, including nutritional optimization and tailored prophylaxis, to improve surgical outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ags3.70236","type":"journal-article","created":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T00:56:26Z","timestamp":1779756986000},"page":"1586-1593","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Lymphocyte\u2010C\u2010Reactive Protein Ratio as Promising New Marker for Predicting Surgical Site Infection in Children With Ulcerative Colitis"],"prefix":"10.1002","volume":"10","author":[{"given":"Yuhki","family":"Koike","sequence":"first","affiliation":[{"name":"Department of Gastrointestinal and Pediatric Surgery Mie University Graduate School of Medicine  Tsu Mie Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koki","family":"Higashi","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal and Pediatric Surgery Mie University Graduate School of Medicine  Tsu Mie Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal and Pediatric Surgery Mie University Graduate School of Medicine  Tsu Mie Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuka","family":"Nagano","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal and Pediatric Surgery Mie University Graduate School of Medicine  Tsu Mie Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadanobu","family":"Shimura","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal and Pediatric Surgery Mie University Graduate School of Medicine  Tsu Mie Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahito","family":"Kitajima","sequence":"additional","affiliation":[{"name":"Department of Genomic Medicine Mie University Graduate School of Medicine  Tsu Mie Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kohei","family":"Matsushita","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal and Pediatric Surgery Mie University Graduate School of Medicine  Tsu Mie Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiki","family":"Okita","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal and Pediatric Surgery Mie University Graduate School of Medicine  Tsu Mie Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshinaga","family":"Okugawa","sequence":"additional","affiliation":[{"name":"Department of Genomic Medicine Mie University Graduate School of Medicine  Tsu Mie 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Healthcare Safety Network Patient Safety Component Manual \u201dSurgical Site Infection (SSI) Event 2024 https:\/\/www.cdc.gov\/nhsn\/pdfs\/pscmanual\/pcsmanual_current.pdf."},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000000568"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/3467419"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00595-013-0809-9"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00595-025-02997-0"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2023.02.042"}],"container-title":["Annals of Gastroenterological 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