{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T05:10:03Z","timestamp":1789017003620,"version":"build-2803163510"},"reference-count":34,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:00:00Z","timestamp":1788912000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:00:00Z","timestamp":1788912000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Annals of Gastroent Surgery"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>This study aims to ascertain the expression status, clinical significance, and biological function of microRNA\u2010941 (miR\u2010941) in colorectal cancer (CRC). It elucidates the role of miR\u2010941 in tumor development and the underlying mechanism involving the transcriptional repressor GATA binding 1 (TRPS1).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Serum samples were collected from 150 CRC patients and 150 healthy controls to examine the relative amounts of miR\u2010941. The diagnostic value of miR\u2010941 was evaluated by plotting receiver operating characteristic (ROC) curves. Kaplan\u2013Meier and Cox regression analyses were employed to assess the prognostic implications of miR\u2010941. Functional experiments were conducted in CRC cell lines. The target gene of miR\u2010941 was identified and confirmed through bioinformatics analysis and a dual\u2010luciferase reporter assay.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      An increased level of miR\u2010941 was found in CRC patients and cell lines (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). The preliminary diagnostic performance showed an area under the ROC curve (AUC) of 0.882. Its high expression was tightly in relation to advanced tumor node metastasis stage, lymph node metastasis, and inferior overall survival, serving as an independent prognostic factor (HR\u2009=\u20092.217,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.005). Functionally, inhibition of miR\u2010941 suppressed cellular behaviors and induced changes with ferroptosis phenotypes. Mechanistically, TRPS1 was predicted and verified to be a direct target of miR\u2010941 at both mRNA and protein levels. Moreover, knockdown of TRPS1 could reverse the tumor\u2010suppressive effects and ferroptosis\u2010related changes caused by miR\u2010941 inhibition.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our results identify miR\u2010941 as a novel oncogenic driver in CRC through targeting of TRPS1, serving as a valuable prognostic indicator.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ags3.70243","type":"journal-article","created":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T04:42:47Z","timestamp":1789015367000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>MicroRNA<\/scp>\n                    \u2010941 Acts as a Novel Prognostic Predictor and Oncogenic Driver in Colorectal Cancer"],"prefix":"10.1002","author":[{"given":"Hong","family":"Li","sequence":"first","affiliation":[{"name":"Department of General Surgery, Changde Hospital, Xiangya School of Medicine Central South University (The First People's Hospital of Changde City)  Changde China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Changde Hospital, Xiangya School of Medicine Central South University (The First People's Hospital of Changde City)  Changde China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Changde Hospital, Xiangya School of Medicine Central South University (The First People's Hospital of Changde City)  Changde China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jialin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Changde Hospital, Xiangya School of Medicine Central South University (The First People's Hospital of Changde City)  Changde China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinchun","family":"Li","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Changde Hospital, Xiangya School of Medicine Central South University (The First People's Hospital of Changde City)  Changde China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-9100-1055","authenticated-orcid":false,"given":"Yanmin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Changde Hospital, Xiangya School of Medicine Central South University (The First People's Hospital of Changde City)  Changde China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,9]]},"reference":[{"issue":"3","key":"e_1_2_9_2_1","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/S2468-1253(21)00426-X","article-title":"The Rising Tide of Early\u2010Onset Colorectal Cancer: A Comprehensive Review of Epidemiology, Clinical Features, Biology, Risk Factors, Prevention, and Early Detection","volume":"7","author":"Patel S. 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