{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T03:26:08Z","timestamp":1793762768126,"version":"4.6.1"},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T00:00:00Z","timestamp":1784160000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T00:00:00Z","timestamp":1784160000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Annals of Gastroent Surgery"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Non\u2010operative management with antibiotics has emerged as an alternative to appendectomy for uncomplicated appendicitis. This study compared one\u2010year healthcare costs and utilization outcomes after operative versus non\u2010operative management of uncomplicated appendicitis using statewide administrative data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a statewide observational study using linked Healthcare Cost and Utilization Project (HCUP) databases from Maryland (2016\u20132021) including emergency department, inpatient, and ambulatory surgery encounters. Adults with uncomplicated appendicitis, identified by ICD\u201010 codes and excluding complicated cases, were analyzed. Operative management was defined as appendectomy during the index hospitalization, non\u2010operative management as initial treatment without appendectomy. The primary outcome was total healthcare cost within one year of the index visit. Secondary outcomes included emergency department revisits, hospital readmissions, and cumulative hospital length of stay. Inverse probability of treatment weighting based on propensity scores was used to balance covariates, and generalized linear models estimated adjusted outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 15\u2009754 patients, 14\u2009056 (89.2%) underwent appendectomy and 1698 (10.8%) received non\u2010operative management. Adjusted mean one\u2010year costs were significantly lower for appendectomy ($6241) than for non\u2010operative management ($8187). Operative management was also associated with fewer emergency department revisits (0.69 vs. 1.00 per patient), fewer readmissions (0.11 vs. 0.34 per patient), and shorter total hospital stays (3.84 vs. 5.87\u2009days) (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Initial appendectomy for uncomplicated appendicitis was associated with lower one\u2010year healthcare costs, fewer emergency department revisits, and fewer readmissions compared with non\u2010operative management. These findings suggest that early surgery may reduce long\u2010term healthcare utilization.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ags3.70248","type":"journal-article","created":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T04:15:24Z","timestamp":1784261724000},"page":"1743-1749","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["One\u2010Year Healthcare Utilization and Costs After Emergency Department Encounters for Uncomplicated Appendicitis: A Statewide Observational Study"],"prefix":"10.1002","volume":"10","author":[{"given":"Andrew C.","family":"Meltzer","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine The George Washington University School of Medicine and Health Sciences  Washington, DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5973-6301","authenticated-orcid":false,"given":"Michael","family":"Makutonin","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Yale University School of Medicine  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taylor","family":"Gorak","sequence":"additional","affiliation":[{"name":"Department of Health Policy and Management The George Washington University Milken Institute School of Public Health  Washington, DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aditya","family":"Loganathan","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine The George Washington University School of Medicine and Health Sciences  Washington, DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack A.","family":"Meltzer","sequence":"additional","affiliation":[{"name":"College of Arts and Sciences University of North Carolina  Chapel Hill North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4475-4333","authenticated-orcid":false,"given":"Avi","family":"Dor","sequence":"additional","affiliation":[{"name":"Department of Health Policy and Management The George Washington University Milken Institute School of Public Health  Washington, DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,16]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.JAA.0000544304.30954.40"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0007-1323.2001.01910.x"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.13201"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2014320"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0220202"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2022.10.036"},{"key":"e_1_2_10_8_1","volume-title":"Economic Evaluation in Clinical Trials","author":"Glick H. 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