{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T05:01:05Z","timestamp":1784869265838,"version":"3.55.0"},"reference-count":55,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T00:00:00Z","timestamp":1784160000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T00:00:00Z","timestamp":1784160000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Annals of Gastroent Surgery"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Accurate pre\u2010treatment evaluation of lymph node metastasis (LNM) in colon cancer is important for determining an optimal treatment strategy. This diagnosis is mainly performed using the size of lymph nodes visualized on CT, although morphological diagnosis is also used.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Meta\u2010analyses of CT for diagnosis of LNM in colon cancer indicate unsatisfactory results, with pooled sensitivities of 71% and 74%, and pooled specificities of 67% and 54%. Our recent report also showed only moderate diagnostic performance, with pooled sensitivity of 66.7%, pooled specificity of 72.4%, and an AUC of the HSROC of 0.741. This is because strict positive criteria based on the size and morphology of visualized lymph nodes are difficult to establish, and currently there are limitations to determining treatment strategies based on imaging diagnosis. Diagnostic accuracy can be improved by setting individualized diagnostic criteria according to the purpose, considering underlying clinicopathological factors, and combining multiple metastasis\u2010related factors. New diagnostic methods such as dual\u2010energy CT and radiomics have also been explored. Unlike traditional diagnoses based on imaging findings, these methods quantify and evaluate parameters, and radiomics, in particular, allows detailed evaluation by quantifying high\u2010dimensional features that are not visible.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Further studies are required to improve diagnostic capabilities that will enable optimal treatment strategies for LNM in colon cancer.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ags3.70250","type":"journal-article","created":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T03:43:27Z","timestamp":1784259807000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Current Status and Challenges of Imaging\u2010Based Diagnosis of Lymph Node Metastasis in Colon Cancer: The Lymph Node Committee of the Japanese Society for Cancer of the Colon and Rectum"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4196-7261","authenticated-orcid":false,"given":"Shimpei","family":"Ogawa","sequence":"first","affiliation":[{"name":"Department of Surgery, Institute of Gastroenterology Tokyo Women's Medical University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7403-1550","authenticated-orcid":false,"given":"Yuji","family":"Takayama","sequence":"additional","affiliation":[{"name":"Department of Surgery, Saitama Medical Center Jichi Medical University  Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9751-3309","authenticated-orcid":false,"given":"Yasuyuki","family":"Takamizawa","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery National Cancer Center Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3366-3826","authenticated-orcid":false,"given":"Yukihide","family":"Kanemitsu","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery National Cancer Center Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8600-1199","authenticated-orcid":false,"given":"Hideki","family":"Ueno","sequence":"additional","affiliation":[{"name":"Department of Surgery National Defense Medical College  Tokorozawa Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,16]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40644-016-0104-2"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00261-019-01900-z"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.15.15785"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6603646"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/codi.15415"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2023.113314"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365521.2011.574732"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00261-024-04373-x"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.12998\/wjcc.v10.i19.6483"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2018.04.008"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10147-025-02899-8"},{"key":"e_1_2_14_13_1","unstructured":"NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines\u00ae) \u201cColon Cancer \u201d(2026) Version 1.2026\u2010March 5 2026 https:\/\/www.nccn.org\/professionals\/physician_gls\/pdf\/colon.pdf."},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.4240\/wjgs.v7.i7.116"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.5152\/dir.2015.15089"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00261-016-0782-z"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0000000000001387"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12957-019-1583-y"},{"issue":"5","key":"e_1_2_14_19_1","first-page":"3451","article-title":"Contrast\u2010Enhanced CT Imaging for the Assessment of Lymph Node Status in Patients With Colorectal Cancer","volume":"19","author":"Miao S. 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