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Identifying B\u2010ALL subtypes can facilitate risk stratification and enable tailored therapeutic design. Existing methods for B\u2010ALL subtyping primarily depend on immunophenotyping, cytogenetic tests, and genomic profiling, which can be costly, complicated, and laborious. To overcome these challenges,\n                    <jats:bold>RanBALL<\/jats:bold>\n                    (an ensemble\n                    <jats:bold>ran<\/jats:bold>\n                    dom projection\u2010based model for identifying\n                    <jats:bold>B<\/jats:bold>\n                    \u2010\n                    <jats:bold>ALL<\/jats:bold>\n                    subtypes) is presented, an accurate and cost\u2010effective model for B\u2010ALL subtype identification. By leveraging random projection (RP) and ensemble learning, RanBALL can preserve patient\u2010to\u2010patient distances after dimension reduction and yield robustly accurate classification performance for B\u2010ALL subtyping. Benchmarking results based on &gt;1700 B\u2010ALL patients demonstrate that RanBALL achieves remarkable performance (accuracy: 0.93, F1\u2010score: 0.93, and Matthews correlation coefficient: 0.93), significantly outperforming state\u2010of\u2010the\u2010art methods like ALLSorts in terms of all performance metrics. In addition, RanBALL performs better than t\u2010SNE in terms of visualizing B\u2010ALL subtype information. We believe RanBALL will facilitate the discovery of B\u2010ALL subtype\u2010specific marker genes and therapeutic targets to have consequential positive impacts on downstream risk stratification and tailored treatment design is believed. To extend its applicability and impacts, a Python\u2010based RanBALL package is available at\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/github.com\/wan-mlab\/RanBALL\">https:\/\/github.com\/wan-mlab\/RanBALL<\/jats:ext-link>\n                    .\n                  <\/jats:p>","DOI":"10.1002\/aisy.202500965","type":"journal-article","created":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T18:30:26Z","timestamp":1761849026000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["RanBALL: An Ensemble Machine Learning Framework for Accurate Subtype Identification of Pediatric B\u2010Cell Acute Lymphoblastic Leukemia"],"prefix":"10.1002","volume":"8","author":[{"given":"Lusheng","family":"Li","sequence":"first","affiliation":[{"name":"Department of Genetics Cell Biology and Anatomy University of Nebraska Medical Center  Omaha NE 68198 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanyu","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Genetics Cell Biology and Anatomy University of Nebraska Medical Center  Omaha NE 68198 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinchao","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Genetics Cell Biology and Anatomy University of Nebraska Medical Center  Omaha NE 68198 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenya","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Pathology, Microbiology and Immunology University of Nebraska Medical Center  Omaha NE 68198 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph D.","family":"Khoury","sequence":"additional","affiliation":[{"name":"Department of Pathology, Microbiology and Immunology University of Nebraska Medical Center  Omaha NE 68198 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jieqiong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurological Sciences University of Nebraska Medical Center  Omaha NE 68198 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0661-2684","authenticated-orcid":false,"given":"Shibiao","family":"Wan","sequence":"additional","affiliation":[{"name":"Department of Genetics Cell Biology and Anatomy University of Nebraska Medical Center  Omaha NE 68198 USA"},{"name":"Fred and Pamela Buffett Cancer Center University of Nebraska Medical Center  Omaha NE 68198 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,30]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1400972"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13225653"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2018.207506"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/HS9.0000000000000700"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.30.1382"},{"key":"e_1_2_9_7_1","first-page":"101095","volume-title":"Acute Leuk Myelodysplasia Adv Controv","author":"Mullighan C. 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