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Maintaining the patency of airway prosthetic devices such as stents and endotracheal tubes also requires effective clearance. Current approaches, primarily blind suction, are ineffective against viscous mucus and risk tissue trauma. Here, it proposes a mucus\u2010cleaning catheter that integrates a rotational soft ciliary brush with suction for efficient and safe clearance on tracheobronchial tissues and within airway prosthetic devices. The soft artificial cilia efficiently wrap up mucus around the suction inlets for removing viscous mucus while a haptic sensing unit provides real\u2010time feedback for operational safety. The device can remove mucus in thin layers without damaging the tissue, typically difficult for pure suction by a therapeutic bronchoscope. This study demonstrates that the device can access airway phantom models, ex\u2009vivo ovine lungs, airway stents, and endotracheal tubes, performing on\u2010demand mucus clearance under real\u2010time visualization via an onboard camera. Compared with therapeutic bronchoscopes with pure suction, the catheter provides faster clearance and minimal damage to tissues, offering a promising strategy for safe, efficient, and timely mucus cleaning for patients with excessive mucus accumulation in the airway.<\/jats:p>","DOI":"10.1002\/aisy.202501236","type":"journal-article","created":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T04:23:03Z","timestamp":1767759783000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Soft Artificial Ciliary Brush with Integrated Haptic Feedback for Efficient Airway Mucus Cleaning"],"prefix":"10.1002","volume":"8","author":[{"given":"Zhongming","family":"Lyu","sequence":"first","affiliation":[{"name":"Department of Mechanical Engineering Vanderbilt University  Nashville 37212 TN US"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusheng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering Vanderbilt University  Nashville 37212 TN US"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruijian","family":"Ge","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering Vanderbilt University  Nashville 37212 TN US"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darren","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering Vanderbilt University  Nashville 37212 TN US"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Bacchetta","sequence":"additional","affiliation":[{"name":"Division of Allergy Pulmonary and Critical Care Medicine School of Medicine Vanderbilt University  Nashville TN 37232 US"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caitlin T.","family":"Demarest","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Vanderbilt University Medical Center  Nashville TN 37232 US"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabien","family":"Maldonado","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering Vanderbilt University  Nashville 37212 TN US"},{"name":"Division of Allergy Pulmonary and Critical Care Medicine School of Medicine Vanderbilt University  Nashville TN 37232 US"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9150-4014","authenticated-orcid":false,"given":"Xiaoguang","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering Vanderbilt University  Nashville 37212 TN US"},{"name":"Department of Biomedical Engineering Vanderbilt University  Nashville 37212 TN US"},{"name":"Vanderbilt Institute for Surgery and Engineering Vanderbilt University  Nashville 37212 TN US"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,6]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01297-2018"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.2147\/COPD.S38938"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prrv.2007.02.004"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.24530"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0910061"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a028241"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a009720"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00238.2019"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.21037\/acs.2018.03.08"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/admt.202301003"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.21037\/jtd-21-1871"},{"key":"e_1_2_9_13_1","first-page":"CD011231","article-title":"Airway Clearance Techniques for Cystic Fibrosis: an Overview of Cochrane Systematic Reviews","volume":"2019","author":"Wilson L. 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