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In the current ultrastructural study rats were given either dihydrobetaerythroidine, metrazol, curare, botulinum toxin, fluoroacetate, fluorocitrate, <jats:italic>Bungarus multicinctus<\/jats:italic> venom, <jats:italic>Naja naja<\/jats:italic> venom, tetrodotoxin or potassium cyanide while other animals were given first one of these agents and then strychnine. Alterations in the endoplasmic reticulum and the presence of intramitochondrial granules were noted only when strychnine was given alone or in combination with one of the other agents.<\/jats:p><jats:p>These results indicate that convulsive activity, release of transmitter substance at the neuromuscular junction, exhaustion of the transmitter substances from the motor neurons during excessive discharge, interruption of oxidative phosphorylation or the direct action of strychnine on the neuronal membrane does not result in changes such as are seen after an injection of strychnine alone. Tentatively, we propose that strychnine alters neuronal membrane permeability with consequent disruption of the ionic equilibrium of the neuron, which is reflected as dilated endoplasmic reticulum, and the presence of intramitochondrial granules.<\/jats:p>","DOI":"10.1002\/aja.1001350304","type":"journal-article","created":{"date-parts":[[2005,2,26]],"date-time":"2005-02-26T14:26:18Z","timestamp":1109427978000},"page":"345-357","source":"Crossref","is-referenced-by-count":4,"title":["Ultrastructural studies of the effects of various agents on the motor neurons of the spinal cord"],"prefix":"10.1002","volume":"135","author":[{"given":"Robert D.","family":"Yates","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jane C.","family":"Yates","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,2,3]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-3002(59)90022-8"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj0790080"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1152\/jn.1968.31.2.186","article-title":"Action of tetrodotoxin on spinal motoneurons of the cat","volume":"31","author":"Blankenship J. 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