{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T17:10:34Z","timestamp":1760980234892},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,2,3]],"date-time":"2005-02-03T00:00:00Z","timestamp":1107388800000},"content-version":"vor","delay-in-days":10871,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Anat."],"published-print":{"date-parts":[[1975,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Developing lymph nodes from 30 human fetuses with crownrump lengths (CRL) of 38 mm (8.7 wk) to 245 mm (26 wk) were studied by light and electron microscopy. Blood vessels that appear to be postcapillary venules (PCV) are present in nodes of 47 mm CRL and older fetuses. These venules first appear in nodes when the nodal population of lymphocytes is sparse. In these early nodes PCV are distributed randomly and consist of a low endothelium, underlying basal lamina and incomplete pericyte sheath. Early nodal PCV are distinguished from other nodal blood vessels by the presence of lymphocyte diapedesis and several luminal lymphocytes.<\/jats:p><jats:p>In the late stages of nodal development PCV are the more common noncapillary blood vessel and appear in the parenchyma near the periphery of the node. Late nodal PCV are generally characterized by a cuboidal endothelium that is rich in Golgi apparatus, lysosomes and Weibel\u2010Palade bodies. The lumen and wall of late nodal PCV contain lymphocytes.<\/jats:p><jats:p>The relationship between the development of the parenchyma of fetal nodes and the appearance and activity of PCV, the passage of lymphocytes through the PCV wall and the fine structure of developing PCV are described. It is suggested that the lymphocytes that first appear in developing nodes, and the majority of the lymphocytes found in late nodes, migrate to the node via the blood vascular system and enter the nodal parenchyma by passing across PCV endothelium.<\/jats:p>","DOI":"10.1002\/aja.1001430103","type":"journal-article","created":{"date-parts":[[2005,2,26]],"date-time":"2005-02-26T18:56:11Z","timestamp":1109444171000},"page":"43-57","source":"Crossref","is-referenced-by-count":28,"title":["Light and electron microscopic studies of postcapillary venules in developing human fetal lymph nodes"],"prefix":"10.1002","volume":"143","author":[{"given":"Raymond P.","family":"Bailey","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leon","family":"Weiss","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,2,3]]},"reference":[{"key":"e_1_2_1_2_1","unstructured":"Anderson A. 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