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Capping each dermal papilla was a two\u2010layered epithelium that protruded slightly above the lingual surface, thus forming the early filiform papilla. In the next stage of development, at 18\u201319 days of gestation, the epithelium lining the papilla had differentiated into two cell populations, one producing hard keratin, the other producing soft keratin. Some of the keratinized epithelial cells assumed a position at an acute angle to the tongue surface and extended deep into the epithelium. In the next stage, 20\u201321 days, a cleft appeared within these angularly oriented cells. This resulted in the division of the epithelium into keratin\u2010lined individual filiform papillae. Finally, the individual papillae increased in size to the adult form.<\/jats:p>","DOI":"10.1002\/aja.1001430303","type":"journal-article","created":{"date-parts":[[2005,2,26]],"date-time":"2005-02-26T18:55:42Z","timestamp":1109444142000},"page":"283-301","source":"Crossref","is-referenced-by-count":52,"title":["Morphogenesis of rat lingual filiform papillae"],"prefix":"10.1002","volume":"143","author":[{"given":"Robert S.","family":"Baratz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Albert I.","family":"Farbman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,2,3]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"100","article-title":"The regeneration of lingual papillae and taste buds after cautery","volume":"16","author":"Arey L. B.","year":"1942","journal-title":"Quart. Bull. 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