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Granule\u2010containing cells appear in the 12 mm embryo and continue to increase in number as the cellular aggregation increases in size and becomes separated from the wall of the third branchial artery. Synapse formation and the appearance of fenestrated capillaries occur almost simultaneously at the 17 mm stage. There are two types of synapses, one with membrane densification and vesicles clustered inside the nerve endings, the other with dense material and vesicles inside the granule\u2010containing cells. At the 20 mm stage the undifferentiated cells send enveloping cytoplasmic processes toward adjacent granule\u2010containing cells and the carotid body anlage displays rudimentary lobules.<\/jats:p>","DOI":"10.1002\/aja.1001440303","type":"journal-article","created":{"date-parts":[[2005,2,26]],"date-time":"2005-02-26T13:59:41Z","timestamp":1109426381000},"page":"275-293","source":"Crossref","is-referenced-by-count":40,"title":["A light and electron microscopic study on the embryonic development of the rat carotid body"],"prefix":"10.1002","volume":"144","author":[{"given":"Hisatake","family":"Kondo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,2,3]]},"reference":[{"key":"e_1_2_1_2_1","volume-title":"The comparative morphology of the carotid body and carotid sinus","author":"Adams W. 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