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The preferential channel, from terminal arteriole to collecting venule, has been examined.<\/jats:p><jats:p>In the terminal arteriolar segment the endothelial layer is covered by a continuous layer of smooth muscle cells which, in turn, are surrounded by adventitia. In the metarteriolar segment the periendothelial cells still resemble smooth muscle cells but the tunica media is discontinuous. In the distal segment periendothelial cells are more scattered and have the appearance of pericytes. There appears to be a continuous transition of the periendothelial cell layer from terminal arteriole to distal segment.<\/jats:p><jats:p>Nerve endings were seen in both the terminal arteriolar and metarteriolar segments.<\/jats:p><jats:p>During contraction smooth muscle cells, oriented circumferentially, shorten and thicken. Endothelial cells appear anchored by myoendothelial junctions.<\/jats:p><jats:p>Endothelial cells have filaments which show increased banding during vasoconstriction, suggesting that such cells may contract.<\/jats:p><jats:p>Capillary offshoots leave the preferential channel, usually at right angles. Smooth muscle cells are oriented to form a sphincter and there are many myoendothelial junctions at the branch point. Within a short distance the capillary branch loses its periendothelial coat.<\/jats:p>","DOI":"10.1002\/aja.1001460404","type":"journal-article","created":{"date-parts":[[2005,2,26]],"date-time":"2005-02-26T13:49:37Z","timestamp":1109425777000},"page":"385-425","source":"Crossref","is-referenced-by-count":19,"title":["Observations on the microcirculatory bed in rat mesocecum using differential interference contrast microscopy in vivo and electron microscopy"],"prefix":"10.1002","volume":"146","author":[{"given":"W. 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