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In addition, emiocytotic events were observed in alpha cells as early as the fifth embryonic day. The early appearance of glucagon and its subsequent developmental profile correlate well with major events in carbohydrate metabolism occurring in the embryonic chick, and are discussed in relation to a functionally responding system, the developing liver. The present data show that glucagon is secreted at earlier embryonic stages than hitherto demonstrated, and suggest a developmental role for glucagon in hepatic glycogen metabolism.<\/jats:p>","DOI":"10.1002\/aja.1001470303","type":"journal-article","created":{"date-parts":[[2005,2,26]],"date-time":"2005-02-26T13:53:19Z","timestamp":1109425999000},"page":"273-279","source":"Crossref","is-referenced-by-count":4,"title":["Functional differentiation of the chick endocrine pancreas. II. 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