{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T20:03:03Z","timestamp":1760644983426},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,2,3]],"date-time":"2005-02-03T00:00:00Z","timestamp":1107388800000},"content-version":"vor","delay-in-days":10260,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Anat."],"published-print":{"date-parts":[[1977,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The parathyroid gland of healthy senile dogs aged 8.5 to 15 years was compared with that of mature control dogs by examination with the electron microscope. Preparations fixed by perfusion with glutaraldehyde showed the cytoplasmic matrix of most parenchymal cells to be uniformly dense. None of the cells were of the extremely light type and dark cells were much less frequently noted than in preparations fixed by immersion in glutaraldehyde or osmium tetroxide. Syncytial cells and so\u2010called colloid follicles were more frequent in senile dogs than in control dogs. It was suggested that the content of the latter structures is not colloid but necrotic substance having origin from the parenchymal cells and that perhaps the occasional cells containing large, membrane\u2010bound inclusions may be degenerating cells which ultimately produce this necrotic substance. Oxyphil cells and mitochondria\u2010rich cells of another type were found in all senile dogs, but not in the controls. These cells, especially the mitochondria\u2010rich cells, frequently contained bizarre mitochondria that were modified in shape, size and arrangement. The most striking feature of these mitochondria was the concentric arrangement of elongated mitochondria which seemed to consist of densely layered cup\u2010shaped mitochondria. Such mitochondria were noted in all senile dogs aged ten years and over. The significance of mitochondrial pleomorphism in the parathyroid gland of senile dogs was discussed.<\/jats:p>","DOI":"10.1002\/aja.1001480107","type":"journal-article","created":{"date-parts":[[2005,2,26]],"date-time":"2005-02-26T13:53:20Z","timestamp":1109426000000},"page":"65-83","source":"Crossref","is-referenced-by-count":28,"title":["Electron microscopic studies of the parathyroid gland of senile dogs"],"prefix":"10.1002","volume":"148","author":[{"given":"Takao","family":"Setoguti","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,2,3]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00542938"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00543363"},{"key":"e_1_2_1_4_1","first-page":"137","volume-title":"Handbuch der mikroskopischen Anatomie des Menschen","author":"Bargmann W.","year":"1939"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.39.3.501"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1090980306"},{"key":"e_1_2_1_7_1","first-page":"95","article-title":"Parathyroid morphology in normal dogs","volume":"8","author":"Bergdahl L.","year":"1973","journal-title":"Path. Europ."},{"key":"e_1_2_1_8_1","first-page":"225","article-title":"Correlative light and electron microscopy in primary hyperparathyroidism","volume":"88","author":"Black W. C.","year":"1969","journal-title":"Arch. Path."},{"key":"e_1_2_1_9_1","first-page":"313","article-title":"Follicles in human parathyroid glands","volume":"28","author":"Boquist L.","year":"1973","journal-title":"Lab. Invest."},{"key":"e_1_2_1_10_1","first-page":"539","article-title":"Parathyroid morphology in gerbils after thyroidectomy and calcium administration","volume":"83","author":"Boquist L.","year":"1975","journal-title":"Acta path. microbiol. scand. Sect. A"},{"key":"e_1_2_1_11_1","first-page":"142","article-title":"Influence of vitamin D on calcium metabolism and the parathyroid gland of cattle","volume":"27","author":"Capen C. C.","year":"1968","journal-title":"Fed. Proc."},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4827(59)90323-4"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmor.1051380202"},{"key":"e_1_2_1_14_1","first-page":"200","article-title":"Fine structure of parathyroid adenomas","volume":"91","author":"Elliot R. L.","year":"1966","journal-title":"Arch. Path."},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711020402"},{"key":"e_1_2_1_16_1","first-page":"37","article-title":"Electron microscopic observations of the equine parathyroid glands with particular reference to those of equine osteodystrophia fibrosa","volume":"15","author":"Fujimoto Y.","year":"1967","journal-title":"Ja. J. Veterinary Research"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj1954.17.355"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00410659"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4800(63)90016-9"},{"key":"e_1_2_1_20_1","first-page":"937","article-title":"Some observations on mitochondria in muscle fibers of Salamandra salamandra (L.)","volume":"88","author":"Kordylewski L.","year":"1974","journal-title":"Z. mikrosk. anat. Forsch"},{"key":"e_1_2_1_21_1","article-title":"Spontaneous hyperparathyroidism. A pathological\u2010anatomical study","volume":"41","author":"Krook L.","year":"1957","journal-title":"Acta path. microbiol. Scandinavica. Suppl. 122"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00345156"},{"key":"e_1_2_1_23_1","first-page":"611","article-title":"Mitochondrial structure in the rat adrenal cortex","volume":"119","author":"Merry B. J.","year":"1975","journal-title":"J. Anat."},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.16.2.379"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1679\/aohc1950.32.155"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1679\/aohc1950.25.435"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0005-8165(75)80005-9"},{"key":"e_1_2_1_28_1","first-page":"516","article-title":"Mitochondrial and other ultrastructural changes in great alveolar cells of oxygen\u2010adapted and posiend rats","volume":"20","author":"Rosenbaum R. M.","year":"1969","journal-title":"Lab. Invest."},{"key":"e_1_2_1_29_1","first-page":"495","article-title":"Pathology of the parathyroids in hyperparathyroidism","volume":"73","author":"Roth S. I.","year":"1962","journal-title":"Arch. Pathol."},{"key":"e_1_2_1_30_1","first-page":"233","article-title":"The ultrastructure of primary water\u2010clear cell hyperplasia of the parathyroid gland","volume":"61","author":"Roth S. I.","year":"1970","journal-title":"Am. J. Pathol."},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00957031"},{"key":"e_1_2_1_32_1","first-page":"435","article-title":"The electron microscopic study of the bat parathyroid gland, with special reference to its seasonal changes","volume":"83","author":"Sakuma H.","year":"1974","journal-title":"J. Kyoto Pref. Univ. Med."},{"key":"e_1_2_1_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5320(64)80016-2"},{"key":"e_1_2_1_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5320(66)80006-0"},{"key":"e_1_2_1_35_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.24.3.500"},{"key":"e_1_2_1_36_1","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1007\/BF00347078","article-title":"Observations ultrastructurales sur la parathyroids de souris. II. Etude exp\u00e9rimentale","volume":"73","author":"Stoeckel M. E.","year":"1966","journal-title":"Z. Zellforsch."},{"key":"e_1_2_1_37_1","first-page":"55","article-title":"Observations ultrastructurales sur la parathyroide de mammif\u00e9re et doiseau dans les conditions normales et exp\u00e9rimentales","volume":"62","author":"Stoeckel M. E.","year":"1973","journal-title":"Arch. d'Anatomie microscopique"},{"key":"e_1_2_1_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5320(64)90034-6"},{"key":"e_1_2_1_39_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.4.1.13"},{"key":"e_1_2_1_40_1","first-page":"334","article-title":"An electron microscopic study of the parathyroid glands in man: evidence of secretory material","volume":"61","author":"Weymouth R. J.","year":"1969","journal-title":"Acta Endcrinol."},{"key":"e_1_2_1_41_1","first-page":"529","article-title":"Fine structure of human parathyroid glands: normal and pathological","volume":"53","author":"Weymouth R. J.","year":"1966","journal-title":"Acta endocrinologia"}],"container-title":["American Journal of Anatomy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Faja.1001480107","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/aja.1001480107","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T10:20:14Z","timestamp":1698834014000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/aja.1001480107"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1977,1]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1977,1]]}},"alternative-id":["10.1002\/aja.1001480107"],"URL":"https:\/\/doi.org\/10.1002\/aja.1001480107","archive":["Portico"],"relation":{},"ISSN":["0002-9106","1553-0795"],"issn-type":[{"value":"0002-9106","type":"print"},{"value":"1553-0795","type":"electronic"}],"subject":[],"published":{"date-parts":[[1977,1]]}}}