{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,11]],"date-time":"2023-11-11T18:00:04Z","timestamp":1699725604208},"reference-count":14,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,2,3]],"date-time":"2005-02-03T00:00:00Z","timestamp":1107388800000},"content-version":"vor","delay-in-days":10201,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Anat."],"published-print":{"date-parts":[[1977,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The ascending colon of a guinea pig injected with tritiated thymidine was cut serially, autoradiographed and stained with periodic\u2010acid\u2010Schiff\u2010hematoxylin. Maps of transversely sectioned crypts were prepared with the use of a microscope eye\u2010piece projector. The number and angular positions of pulselabelled (DNA\u2010synthesizing) cells around the circumference of transverse sections of the crypt were recorded. A method of \u201cstatistics of the circumference\u201d was applied in order to find the variances of angular distances between labelled cells and thereby to find the type of arrangement of DNA\u2010synthesizinbg cells in the crypt.<\/jats:p><jats:p>The spatial distribution of DNA\u2010synthesizing cells, both around the crypt circumference and along the crypt, was found to be non\u2010random. While the pattern of nonrandomness around the crypt circumference is such that the DNA\u2010synthesizing cells tend to occupy positions in the crypt circumference at maximal distances from each other, DNA\u2010synthesizing cells along the crypt tend to occupy positions at minimal distances from each other. DNA\u2010synthesizing cells are arranged in the crypt in rows, each consisting of several cells and each parallel to the long axis of the crypt. Apparently the dividing cell of the crypt produces either two proliferating or two differentiating cells. No evidence of differential mitosis could be found.<\/jats:p>","DOI":"10.1002\/aja.1001480309","type":"journal-article","created":{"date-parts":[[2005,2,26]],"date-time":"2005-02-26T13:25:40Z","timestamp":1109424340000},"page":"417-425","source":"Crossref","is-referenced-by-count":7,"title":["Spatial distribution of DNA\u2010synthesizing cells in colonic crypts of the guinea pig"],"prefix":"10.1002","volume":"148","author":[{"given":"Wojciech","family":"Sawicki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olena","family":"Blaton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maciej","family":"Pindor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,2,3]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4827(67)90079-1"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4827(65)90055-8"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.1030660315"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.140.3566.487"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00225771"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1090330502"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1090550402"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001170106"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001450102"},{"key":"e_1_2_1_11_1","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1093\/oxfordjournals.bmb.a069976","article-title":"The cancer cell","volume":"18","author":"Mercer E. H.","year":"1962","journal-title":"Brit. Med. Bull."},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001350407"},{"key":"e_1_2_1_13_1","first-page":"375","article-title":"Proliferation kinetics in epithelium of guinea\u2010pig colon. I. Variations depending on crypt length and its localization","volume":"3","author":"Sawicki W.","year":"1970","journal-title":"Cell. Tiss. Kinet."},{"key":"e_1_2_1_14_1","first-page":"225","article-title":"Proliferation kinetics in epithelium guinea\u2010pig colon. II. Distribution of proliferating and specialized cells along various crypts","volume":"4","author":"Sawicki W.","year":"1971","journal-title":"Cell. Tiss. Kinet."},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1091350103"}],"container-title":["American Journal of Anatomy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Faja.1001480309","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/aja.1001480309","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T12:43:21Z","timestamp":1698842601000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/aja.1001480309"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1977,3]]},"references-count":14,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1977,3]]}},"alternative-id":["10.1002\/aja.1001480309"],"URL":"https:\/\/doi.org\/10.1002\/aja.1001480309","archive":["Portico"],"relation":{},"ISSN":["0002-9106","1553-0795"],"issn-type":[{"value":"0002-9106","type":"print"},{"value":"1553-0795","type":"electronic"}],"subject":[],"published":{"date-parts":[[1977,3]]}}}