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A pronounced decrease in the number and size of matrix granules (proteoglycans) was found in the cartilaginous matrix of triamcinolone\u2010treated condyles. In contrast, a marked increase concomitant with significant structural changes was noted in collagen fibrils. An obvious enhancement of collagen fibrillogenesis was noticed in the pre\u2010mineralizing extracellular matrix. Atypical, wider than normal, banded collagen fibrils were found to form dense meshworks which appeared to lack any specific orientation or organization. It is proposed that glucocorticoid hormones, given systemically to neonatal mice, interfere with regulatory mechanisms involved with the biosynthesis of cartilaginous matrical macromolecules, i.e., proteoglycans and collagen and thereby promote certain aging processes within active growth centers.<\/jats:p>","DOI":"10.1002\/aja.1001510406","type":"journal-article","created":{"date-parts":[[2005,2,27]],"date-time":"2005-02-27T03:23:18Z","timestamp":1109474598000},"page":"515-525","source":"Crossref","is-referenced-by-count":3,"title":["Glucocorticoid\u2010induced alterations in collagen of neonatal mouse condylar cartilage"],"prefix":"10.1002","volume":"151","author":[{"given":"Dina","family":"Lewinson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Silbermann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,2,3]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"665","article-title":"Cortisol effect on collagen biosynthesis in embryonic explants and in vitro hydroxylation of protocollagen","volume":"83","author":"Blumenkrantz N.","year":"1976","journal-title":"Acta Endocrin."},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0047-6374(76)90030-0"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02059048"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-197209000-00042"},{"key":"e_1_2_1_6_1","first-page":"267","article-title":"The effect of prolonged prednisone treatment on human costal cartilage","volume":"81","author":"Dearden L. 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