{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T15:42:23Z","timestamp":1759333343986},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,2,3]],"date-time":"2005-02-03T00:00:00Z","timestamp":1107388800000},"content-version":"vor","delay-in-days":9622,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Anat."],"published-print":{"date-parts":[[1978,10]]},"abstract":"Abstract<\/jats:title>The ia<\/jats:italic> (incisors absent) rat is a naturally occurring mutant that has osteopetrosis resulting from reduced bone resorption. A number of in vestigators have reported that other osteopetrotic mutant rats (op) and mice (mi<\/jats:italic> and op<\/jats:italic>), in addition to demonstrating the skeletal manifestations of the disease, have cellular immunological defects. In light of the fact that bone resorption has been demonstrated to be controlled by hematopoietic tissues and more specifically by mononuclear cells isolated from lymphoid organs, it seemed appropriate to investigate immunological competence in the ia<\/jats:italic> rat, to determine whether or not it had this defect in common with the op<\/jats:italic> rat.<\/jats:p>Contrary to the results presented for other osteopetrotic mutants, we found that the thymuses in our ia<\/jats:italic> mutants had a normal cellular composition and the T\u2010cell\u2010dependent zones in the lymph nodes were not deficient in lymphocytes. Therefore, this study was undertaken to investigate the response of ia<\/jats:italic> rats to oxazolone, which produces one type of T\u2010cell\u2010dependent immune response, delayed hypersensitivity.<\/jats:p>The results of these studies indicate that ia<\/jats:italic> rats at 18 days of age have the ability to develop delayed hypersensitivity, as shown by both a blastogenic response in the lymph node draining the site of sensitization and a positive skintest. The magnitudes of these responses were similar in ia<\/jats:italic> and normal littermates, both histologically and quantitatively. Therefore, the ia<\/jats:italic> mutant does not appear to have a defect of the thymus\u2010dependent immune system, and further studies should be carried out to investigate other parameters of immunological competence in these animals.<\/jats:p>","DOI":"10.1002\/aja.1001530209","type":"journal-article","created":{"date-parts":[[2005,2,26]],"date-time":"2005-02-26T13:38:11Z","timestamp":1109425091000},"page":"305-319","source":"Crossref","is-referenced-by-count":7,"title":["The role of lymphoid cells in bone resorption: Cellular immunological competence in ia<\/i> rats"],"prefix":"10.1002","volume":"153","author":[{"given":"Gary B.","family":"Schneider","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,2,3]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"485","article-title":"Contact sensitivity in the mouse. XI. Movement of T blasts in the draining lymph nodes to sites of inflammation","volume":"25","author":"Asherson G. L.","year":"1973","journal-title":"Immunology"},{"key":"e_1_2_1_3_1","unstructured":"Ballet J. J. andC.Griscelli1978Lymphoid cell transplantation in human osteopetrosis. The First Scientific Evaluation Workshop on Localized Bone Loss. In: Calcified Tissue Abs. in press."},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197208242870806"},{"key":"e_1_2_1_5_1","first-page":"111","article-title":"The morphology of immune reactions in normal, thymectomized and reconstituted mice. II. The response to oxazolone","volume":"17","author":"Davies A. J. S.","year":"1969","journal-title":"Immunology"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001220310"},{"key":"e_1_2_1_7_1","first-page":"1073","article-title":"Atteinte de la rate dans l'osteopetrose congenitale du rat (op) Effet curatif de la greffe de thymus","volume":"283","author":"Graf B.","year":"1976","journal-title":"C. R. Acad. Sci. Paris, D."},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.jhered.a104973"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.177.4051.793"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.157.3786.322"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001380204"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1976.tb01760.x"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001460308"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001510110"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001520306"},{"key":"e_1_2_1_16_1","first-page":"531","article-title":"Guerison de l'osteopetrose congenitale du rat (op) par greffe de thymus","volume":"283","author":"Milhaud G.","year":"1976","journal-title":"C. R. Acad. Sci. Paris, D."},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.74.1.339"},{"key":"e_1_2_1_18_1","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1093\/oxfordjournals.jhered.a108554","article-title":"Genetic study of osteopetrosis in the Norway rat","volume":"65","author":"Moutier R.","year":"1974","journal-title":"J. Heredity"},{"key":"e_1_2_1_19_1","unstructured":"Olsen C. E. S. M.Wahl L. M.Wahl A. L.SandbergandS. E.Mergenhagen1978Immunologic defects in osteopetrotic mice. The First Scientific Evaluation Workshop on Localized Bone Loss. In: Calcified Tissue Abs. in press."},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.123.1.191"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.123.1.191"},{"key":"e_1_2_1_21_1","first-page":"387","article-title":"The response of normal, thymectomized and reconstituted mice in contact sensitivity","volume":"18","author":"Parrott D. M. V.","year":"1970","journal-title":"Clin. Exp. Immunol."},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001370303"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001410205"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001450306"},{"key":"e_1_2_1_25_1","first-page":"391","volume-title":"Biometry, the Principles and Practice of Statistics in Biological Research","author":"Sokal R. R.","year":"1969"},{"key":"e_1_2_1_26_1","first-page":"777","article-title":"Effect of hydrocortisone on the reactivity of thymus and spleen cells of mice to in vitro stimulation","volume":"23","author":"Vischer T. 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