{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T00:27:57Z","timestamp":1771633677785,"version":"3.50.1"},"reference-count":47,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,2,3]],"date-time":"2005-02-03T00:00:00Z","timestamp":1107388800000},"content-version":"vor","delay-in-days":9591,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Anat."],"published-print":{"date-parts":[[1978,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Sublingual and submandibular glands were prepared for light and electron microscopy, and for histochemical staining with periodic acid\u2010Schiff (PAS), Alcian Blue (AB) or both (AB\u2010PAS). Between 15 and 17 days post\u2010conception, the sublingual gland undergoes active morphogenesis from a single, solid bud into a branched glandular tree. At 18 days the first overt signs of secretory differentiation appear in the formation of cells with three kinds of secretion granules; that is, electron\u2010dense serous granules, empty\u2010looking mucous granules with fine thread\u2010like substructures, and granules which have the general appearance of mucous granules but also contain an internal, electron\u2010dense core (\u201cmixed\u201d granules). During the period from 18 to 20 days, all three types of granulated cells increase in number, with mucous cells predominating, and they all border directly on the acinar lumina, in seemingly random combinations in different acini. This diversity is reflected in the histochemical staining, since most acini and cells are both PAS\u2010 and AB\u2010positive, but a substantial minority stain only with PAS, indicating that they contain serous granules. By comparison, all secretory cells in the submandibular gland stain with PAS but not with AB after the initial appearance of secretory granules at 18 days. From 20 days to birth (at 22 days), the cells with mixed granules disappear, while the cells with serous granules become fewer in number and displaced to the peripheral outpocketings of the acini. As a result of these changes, the general organization in the newborn is similar to that in the adult, i.e., purely mucous acini with serous demilunes.<\/jats:p>","DOI":"10.1002\/aja.1001530304","type":"journal-article","created":{"date-parts":[[2005,2,26]],"date-time":"2005-02-26T22:29:42Z","timestamp":1109456982000},"page":"367-389","source":"Crossref","is-referenced-by-count":43,"title":["Cytodifferentiation of secretory cells in the sublingual gland of the prenatal rat: A histological, histochemical and ultrastructura study"],"prefix":"10.1002","volume":"153","author":[{"given":"Robert S.","family":"Redman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William D.","family":"Ball","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,2,3]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/jez.1401880304"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(74)90305-4"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-0436.1978.tb00957.x"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.52.3.664"},{"key":"e_1_2_1_6_1","first-page":"431","article-title":"Fine structure of the differentiating acini in submandibular glands of isoproterenol treated rats","volume":"138","author":"Bressler R. 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Cited in the Microtomists' Vade\u2010Mecum","author":"Kahle W.","year":"1908"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5320(71)90020-7"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5320(72)90012-3"},{"key":"e_1_2_1_18_1","first-page":"173","article-title":"Tissue interactions in embryonic mouse tooth germs. II. The inductive role of the dental papilla","volume":"24","author":"Kollar E. J.","year":"1970","journal-title":"J. Embryol. Exp. Morphol."},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00219935"},{"key":"e_1_2_1_20_1","first-page":"139","article-title":"Acinar ultra\u2010structure of the sublingual gland of Mus musculus during embryonic development","volume":"3","author":"Laj M.","year":"1971","journal-title":"J. Submicr. 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