{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:01:31Z","timestamp":1761894091342},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,2,3]],"date-time":"2005-02-03T00:00:00Z","timestamp":1107388800000},"content-version":"vor","delay-in-days":8679,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Anat."],"published-print":{"date-parts":[[1981,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The excessive skeletal mass and reduced bone resorption characteristic of osteopetrosis in microphthalmic <jats:italic>(mi)<\/jats:italic> mice can be corrected by irradiation and transfer of spleen cells from a normal littermate. Osteoclasts in beige <jats:italic>(bg)<\/jats:italic> mice, a mutation without osteopetrosis, have giant lysosomal granules. These two facts were exploited to trace osteoclast lineage.<\/jats:p><jats:p>Microphthalmic mice treated with whole\u2010body irradiation and spleen cells from a beige donor resorbed the excessive skeletal mass and recovered from osteopetrosis. Furthermore, osteoclasts in treated <jats:italic>mi<\/jats:italic> mice had giant lysosomal granules and resembled those found in <jats:italic>bg<\/jats:italic> donors when examined by light and transmission electron microscopy.<\/jats:p><jats:p>These data provide direct evidence for a hematogenous origin of osteoclasts in mammals.<\/jats:p>","DOI":"10.1002\/aja.1001610102","type":"journal-article","created":{"date-parts":[[2005,2,26]],"date-time":"2005-02-26T13:04:09Z","timestamp":1109423049000},"page":"1-10","source":"Crossref","is-referenced-by-count":92,"title":["The hematogenous origin of osteoclasts: Experimental evidence from osteopetrotic (microphthalmic) mice treated with spleen cells from beige mouse donors"],"prefix":"10.1002","volume":"161","author":[{"suffix":"Jr.","given":"Sandy C.","family":"Marks","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donald G.","family":"Walker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,2,3]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/283669a0"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711300405"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/10.6.741"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198003273021301"},{"key":"e_1_2_1_6_1","first-page":"217","article-title":"A hereditary alteration in kidneys of mice with Ch\u00e9diak\u2010Higashi Syndrome","volume":"73","author":"Essner E.","year":"1973","journal-title":"Am. 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