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Embryonic development and mural trophoblast outgrowth were examined by light, transmission and scanning electron microscopy, and by time\u2010lapse cinematography. The results demonstrate that cultured mouse blastocysts are capable of development that is essentially equivalent to the early egg cylinder stage in the presence and absence of a uterine epithelial substratum. Penetration of the endometrium and displacement of uterine luminal epithelial cells in vivo is paralleled in vitro by the displacement of uterine cells from the advancing edge of outgrowing mural trophoblast. The ability of mural trophoblast to continue to outgrow and displace uterine cells persists for a finite period of time. The findings are discussed with respect to (1) the nature of embryo\u2010uterine contact in vivo and (2) mechanisms proposed to explain trophoblastic displacement of uterine luminal epithelial cells during normal implantation.<\/jats:p>","DOI":"10.1002\/aja.1001620206","type":"journal-article","created":{"date-parts":[[2005,2,26]],"date-time":"2005-02-26T18:07:23Z","timestamp":1109441243000},"page":"143-155","source":"Crossref","is-referenced-by-count":21,"title":["Morphodynamics of outgrowths of mouse trophoblast in the presence and absence of a monolayer of uterine epithelium"],"prefix":"10.1002","volume":"162","author":[{"given":"Jonathan","family":"Van Blerkom","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel J.","family":"Chavez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,2,3]]},"reference":[{"key":"e_1_2_1_2_1","volume-title":"Molecular and Cellular Aspects of Implantation","author":"Chavez D. 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