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More significantly, in the fluoride\u2010treated rats, the cytoplasmic organelles of the dark chief cells are even more developed that those seen in the dark chief cells of untreated rats. The dark cells contain an electron\u2010dense cytoplasm with abundant lamellar arrays of rough endoplasmic reticulum, spiral aggregations of free ribosomes, multiple dilated Golgi complexes, and increased numbers of secretory granules. The cells are at a minimum dimension with maximum tortuosity of the plasma membranes; and, as a result, large intercellular spaces are often seen between contiguous cells. Based on these observations, it is suggested that, in the fluoride\u2010treated rat, a type of secondary hyperparathyroidism develops resulting in an increase in the organelles involved in protein synthesis and secretion.<\/jats:p>","DOI":"10.1002\/aja.1001620305","type":"journal-article","created":{"date-parts":[[2005,2,26]],"date-time":"2005-02-26T18:07:26Z","timestamp":1109441246000},"page":"233-241","source":"Crossref","is-referenced-by-count":5,"title":["Fluoride stimulation of the rat parathyroid gland: An ultrastructural study"],"prefix":"10.1002","volume":"162","author":[{"given":"Larry J.","family":"Ream","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Principato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,2,3]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00542938"},{"key":"e_1_2_1_3_1","first-page":"51","article-title":"The effects of fluoride therapy on metabolic bone disease","volume":"55","author":"Baylink D. 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