{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T04:14:23Z","timestamp":1778991263804,"version":"3.51.4"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,2,3]],"date-time":"2005-02-03T00:00:00Z","timestamp":1107388800000},"content-version":"vor","delay-in-days":7095,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Anat."],"published-print":{"date-parts":[[1985,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The effects of the bisphosphonate HEBP on dentin formation and the structural relationship between the dentin and the developing periodontal attachment apparatus have been studied in the continuously growing mouse incisor. It was observed that HEBP (in doses \u2265 8 mg P\/kg b.w\/day) not only inhibited the deposition of mineral crystallites in newly formed dentin matrix, but also entirely prevented the formation of a layer of acellular root cementum. It was further noticed that the drug interfered with the deposition of <jats:sup>3<\/jats:sup>H\u2010serine\u2010containing substances at the predentin\u2010dentin border. This was not always accompanied by an inhibition of dentin mineralization, thereby suggesting that <jats:sup>3<\/jats:sup>H\u2010serine\u2010containing proteins (presumably phosphoproteins) do not play a critical role in the deposition of mineral layers onto previously formed ones. The absence of a cementum layer did not prevent the developing periodontal ligament from establishing matrix\u2010to\u2010matrix connections with the root\u2010analogue dentin. Collagen fibrils of the ligament intermingled with those of the mantle dentin, which in contrast to teeth not exposed to the drug were clearly visible and not masked by electron\u2010dense matrix components. Finally, it was found that the drug had distinct effects on the formation of root\u2010analogue and crown\u2010analogue dentin. Whereas during the course of the experiment the odontoblasts along the crown\u2010analogue aspect of the tooth continued to produce circumpulpal dentin matrix, those along the root\u2010analogue aspect of the tooth did so only when the mantle dentin layer had been mineralized prior to HEBP administration. This phenomenon is interpreted as being indicative of fundamental differences between the formation of crown and root dentin.<\/jats:p>","DOI":"10.1002\/aja.1001740107","type":"journal-article","created":{"date-parts":[[2005,2,26]],"date-time":"2005-02-26T17:21:52Z","timestamp":1109438512000},"page":"83-103","source":"Crossref","is-referenced-by-count":63,"title":["Effects of 1\u2010hydroxyethylidene\u20101, 1\u2010bisphosphonate (HEBP) on the formation of dentin and the periodontal attachment apparatus in the mouse"],"prefix":"10.1002","volume":"174","author":[{"given":"W.","family":"Beertsen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Niehof","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Everts","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,2,3]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1982.tb01185.x"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1983.tb00361.x"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(64)90002-0"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01985657"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02405302"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-0248(81)90059-2"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.1970.tb00591.x"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.165.3899.1264"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1974.45.8.2.626"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1983.54.7.389"},{"key":"e_1_2_1_12_1","first-page":"234","volume-title":"Oral Histology; Development, Structure and Function","author":"Freeman E.","year":"1980"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1978.tb00164.x"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj1840203"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5320(71)80008-4"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-197107000-00021"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02008217"},{"key":"e_1_2_1_18_1","first-page":"147","article-title":"Formation of intermediate cementum: I. 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