{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T02:18:21Z","timestamp":1698200301126},"reference-count":52,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,2,3]],"date-time":"2005-02-03T00:00:00Z","timestamp":1107388800000},"content-version":"vor","delay-in-days":6883,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Anat."],"published-print":{"date-parts":[[1986,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Using scanning electron microscopy (SEM), we show that an in utero exposure to diethylstilbestrol (DES) will induce endometrial abnormalities postnatally. These changes are magnified when a subsequent postnatal DES treatment is given. More specifically, changes in cell surface morphology are associated with alterations in cell size and shape (from columnar to cuboid\/squamous), and in microvilli and mucus secretion. Uteri from hamsters treated postnatally with DES and derived from normal (CD) or DES\u2010treated mothers (DD) show that accumulated mucoid secretion products are not expelled in the uterine lumen but are \u201cstored\u201d in cystic dilated glandular spaces of the fibrocellular stroma of polyps and papillae filling the uterine lumen. Uteri from female hamsters that have been prenatally treated with DES (DC) show endometrial mucosal crypts containing mucus and other cell debris including migrating granulocytes. In all cases, DES\u2010treated uteri show mucosal cell surface pleomorphism in the sequence DD &gt; CD &gt; DC Merocrine and\/or cystic secretions were observed. Microvilli cover cell surfaces and include some rare and peculiar long microvillous growth. In contrast, DC hypoplastic uteri present no secretory activity. Structures similar to those described for CD uteri can be observed only after 250 days of age in DC uteri. This report confirms and complements previous observations, favoring the choice of the hamster as an animal mode for the study of endometrial carcinogenesis.<\/jats:p>","DOI":"10.1002\/aja.1001750404","type":"journal-article","created":{"date-parts":[[2005,2,27]],"date-time":"2005-02-27T03:00:45Z","timestamp":1109473245000},"page":"429-447","source":"Crossref","is-referenced-by-count":5,"title":["Upper genital tract abnormalities in the Syrian hamster as a result of in utero exposure to diethylstilbestrol. II. Scanning electron microscope analysis of endometrium cell surfaces"],"prefix":"10.1002","volume":"175","author":[{"given":"Jacques","family":"Gilloteaux","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan W.","family":"Steggles","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,2,3]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.64.3.692"},{"key":"e_1_2_1_3_1","first-page":"565","article-title":"An ultrastructural comparison of human endometrial adenocarcinoma with normal postmenopausal endometrium","volume":"53","author":"Aycock N. R.","year":"1979","journal-title":"Obstet. Gynecol."},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-67568-3_13"},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/BF02889533","article-title":"Configuration of surfaces of human cancer cells in effusions","volume":"26","author":"Domagala W.","year":"1977","journal-title":"Virchows Arch. [Cell Pathol.]"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001640205"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0344-0338(82)80070-8"},{"key":"e_1_2_1_8_1","first-page":"151","volume-title":"Female reproductive system: Dynamics of scan and transmission electron microscopy","author":"Ferenczy A.","year":"1974"},{"key":"e_1_2_1_9_1","first-page":"94","article-title":"Diethylstilbestrol\u2010induced uterine abnormalities in the Syrian hamster. Observations from scanning electron microscopy","volume":"199","author":"Gilloteaux J.","year":"1981","journal-title":"Anat. Rec."},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1982.tb21476.x"},{"key":"e_1_2_1_11_1","first-page":"217","article-title":"Effects of hormone treatment on the distribution of monoamine oxidase in the Syrian hamster uterus","volume":"29","author":"Gilloteaux J.","year":"1983","journal-title":"Cell Mol. Biol."},{"key":"e_1_2_1_12_1","first-page":"303","article-title":"Endometrium cell surface abnormalities in the Syrian hamster as a result of in utero exposure to diethylstilbestrol","volume":"1","author":"Gilloteaux J.","year":"1985","journal-title":"Scan. Electron Microsc."},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00618867"},{"key":"e_1_2_1_14_1","first-page":"11","article-title":"Hyperplastic lesions of the human breast: Scanning electron microscopy and a review of current knowledge","author":"Halter S. A.","year":"1981","journal-title":"Scan. Electron Microsc."},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)43814-8"},{"key":"e_1_2_1_16_1","first-page":"13","article-title":"Summary of the changes in the human female genital tract as a consequence of maternal diethylstilbestrol therapy","volume":"1","author":"Herbst A. L.","year":"1976","journal-title":"J. Toxicol. Environ. Health, Suppl."},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-67568-3_6"},{"key":"e_1_2_1_18_1","first-page":"25","article-title":"Prenatal diethylstilbestrol exposure and human genital tract abnormalities","volume":"51","author":"Herbst A. L.","year":"1979","journal-title":"Natl. Cancer Inst. Monogr."},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(77)90294-0"},{"key":"e_1_2_1_20_1","first-page":"23","article-title":"Cell surface morphology in epithelial malignancy and its precursor lesions","author":"Kenemans P.","year":"1981","journal-title":"Scan. Electron Microsc."},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711050103"},{"key":"e_1_2_1_22_1","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/BF02889300","article-title":"Deletion of cells by apoptosis during castration\u2010induced involution of the rat prostate","volume":"13","author":"Kerr J. F. R.","year":"1973","journal-title":"Virchows Arch. [Cell Pathol.]"},{"key":"e_1_2_1_23_1","first-page":"341","volume-title":"Scanning Electron Microscopy in Cell Biology and Medicine","author":"K\u00fchnel W.","year":"1981"},{"key":"e_1_2_1_24_1","first-page":"4057","article-title":"Visualization by light and scanning electron microscopy of reproductive tract lesions in female mice treated transplacentally with diethylstilbestrol","volume":"41","author":"Lamb J. C.","year":"1981","journal-title":"Cancer Res."},{"key":"e_1_2_1_25_1","first-page":"63","volume-title":"Hormones and Cancer","author":"Leavitt W. W.","year":"1980"},{"key":"e_1_2_1_26_1","first-page":"61","article-title":"Transplacental effects of diethylstilbestrol in mice","volume":"51","author":"McLachlan J. A.","year":"1979","journal-title":"Natl. Cancer Inst. Monogr."},{"key":"e_1_2_1_27_1","first-page":"3988","article-title":"Long term effects on the female mouse genital tract associated with prenatal exposure to diethylstilbestrol","volume":"40","author":"McLachlan J. A.","year":"1980","journal-title":"Cancer Res."},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(74)90234-8"},{"key":"e_1_2_1_29_1","first-page":"315","article-title":"Scanning electron microscopy of the endometrium during the secretory phase","volume":"122","author":"Motta P. M.","year":"1976","journal-title":"J. Anat."},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.3109\/03009737809179133"},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.3109\/03009738009179166"},{"key":"e_1_2_1_32_1","first-page":"121","article-title":"Longterm responses of the mouse uterus to neonatal diethylstilbestrol treatment and to later sex hormone exposure","volume":"74","author":"Ostrander P. L.","year":"1985","journal-title":"J. Natl. Cancer Inst."},{"key":"e_1_2_1_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00315077"},{"key":"e_1_2_1_34_1","first-page":"161","article-title":"An ultrastructural study of implantation in the golden hamster","volume":"121","author":"Parkening T. A.","year":"1976","journal-title":"J. Anat."},{"key":"e_1_2_1_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/geronj\/34.3.335"},{"key":"e_1_2_1_36_1","first-page":"4667","article-title":"Morphological effects of diethylstilbestrol on neonatal mouse uterus and vagina","volume":"41","author":"Plapinger L.","year":"1981","journal-title":"Cancer Res."},{"key":"e_1_2_1_37_1","first-page":"507","article-title":"Adenosis\u2010like lesions and other cervicovaginal abnormalities in mice treated perinatally with estrogen","volume":"63","author":"Plapinger L.","year":"1979","journal-title":"J. Natl. Cancer Inst."},{"key":"e_1_2_1_38_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.97.3.679"},{"key":"e_1_2_1_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/0090-8258(74)90008-0"},{"key":"e_1_2_1_40_1","first-page":"309","article-title":"Pathologic findings in young women enrolled in the National Cooperative Diethylstilbestrol Adenosis (DESAD) Project","volume":"53","author":"Robboy S. J.","year":"1979","journal-title":"Obstet. Gynecol."},{"key":"e_1_2_1_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3835(75)96099-1"},{"key":"e_1_2_1_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001560103"},{"key":"e_1_2_1_43_1","first-page":"125","volume-title":"Scanning Electron Microscopy in Cell Biology and Medicine","author":"Sawada H.","year":"1981"},{"key":"e_1_2_1_44_1","first-page":"188","article-title":"Ultrastructure of ciliated cells in the human endometrium","volume":"41","author":"Schueller E. F.","year":"1973","journal-title":"Obstet. Gynecol."},{"key":"e_1_2_1_45_1","series-title":"Proc. Symp. DES 1977, Am. Coll. Obstet. Gynecol.","first-page":"8","volume-title":"Intrauterine Exposure to Diethylstilbestrol in the Human","author":"Scully R. E.","year":"1978"},{"key":"e_1_2_1_46_1","first-page":"281","article-title":"Ultrastructural aspects of uterine secretion during the establishment of pregnancy in the rabbit: Role of the egg","volume":"135","author":"Segalen J.","year":"1982","journal-title":"J. Anat."},{"key":"e_1_2_1_47_1","first-page":"18","article-title":"Reproductive tract abnormalities in the female Syrian hamster as a result of prenatal and postnatal exposure to diethylstilbestrol","volume":"87","author":"Steggles A. W.","year":"1980","journal-title":"J. Cell Biol."},{"key":"e_1_2_1_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/0028-2243(80)90012-X"},{"key":"e_1_2_1_49_1","doi-asserted-by":"publisher","DOI":"10.2183\/pjab1945.40.42"},{"key":"e_1_2_1_50_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/70.5.770"},{"key":"e_1_2_1_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1981.tb02227.x"},{"key":"e_1_2_1_52_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.136.3.7403556"},{"key":"e_1_2_1_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0074-7696(08)62312-8"}],"container-title":["American Journal of Anatomy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Faja.1001750404","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/aja.1001750404","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T22:18:22Z","timestamp":1697840302000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/aja.1001750404"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,4]]},"references-count":52,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1986,4]]}},"alternative-id":["10.1002\/aja.1001750404"],"URL":"https:\/\/doi.org\/10.1002\/aja.1001750404","archive":["Portico"],"relation":{},"ISSN":["0002-9106","1553-0795"],"issn-type":[{"value":"0002-9106","type":"print"},{"value":"1553-0795","type":"electronic"}],"subject":[],"published":{"date-parts":[[1986,4]]}}}