{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T13:40:03Z","timestamp":1697982003218},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,2,3]],"date-time":"2005-02-03T00:00:00Z","timestamp":1107388800000},"content-version":"vor","delay-in-days":6669,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Anat."],"published-print":{"date-parts":[[1986,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Twenty\u2010seven male albino rats underwent hindlimb amputations through the lower femur or the midshaft of the tibiofibula on the tenth to 12th day of life. Amputation stumps were examined grossly and histologically in order to assess the significance of level and angle of transection as determinants of subsequent growth and regeneration and to ascertain whether growth plates can regenerate following their complete excision. Amputees survived for 17\u201373 days. In order to exclude limbs which had been severed at or distal to the level of the growth plate, amputated limb segments either were cleared to transparency and inspected under low magnification or were sectioned serially and examined by using a compound microscope. Following amputations through the femur, the predominant response involved repair of the skeletal defect and healing of adjacent soft tissues (ten of 17 rats). Among five other animals the skeletal terminus was covered with a plate of cartilage which, in three, included areas of growth\u2010plate architecture. Two additional transfemoral amputees regenerated incomplete growth plates, each overlying a single epicondylar surface, and one provided with a regenerated hemiepiphysis. Five of ten transtibiofibular amputees formed cartilage plates which covered the skeletal terminus in whole or in part and one regenerated an entire growth plate restricted to the distal fibula. It is concluded that angle and level of transection are not pivotal modifiers of growth and regeneration processes, and that distal growth plates may regenerate entirely or in part following their complete removal from the hindlimb.<\/jats:p>","DOI":"10.1002\/aja.1001770307","type":"journal-article","created":{"date-parts":[[2005,2,27]],"date-time":"2005-02-27T02:43:01Z","timestamp":1109472181000},"page":"369-383","source":"Crossref","is-referenced-by-count":8,"title":["Regeneration of growth plates in the long bones of the neonatal rat hindlimb"],"prefix":"10.1002","volume":"177","author":[{"given":"Richard M.","family":"Libbin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Weinstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,2,3]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-194112000-00014"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7100922"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1093\/icb\/18.4.869","article-title":"Types of morphogenetic phenomena in vertebrate regenerating systems","volume":"18","author":"Carlson B. M.","year":"1978","journal-title":"Am. Zool."},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1090310102"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1090430202"},{"key":"e_1_2_1_7_1","first-page":"86","article-title":"Conservative management of guilotine amputation of the fingers in children","volume":"8","author":"Douglas B. S.","year":"1972","journal-title":"Aust. Paediatr. J."},{"key":"e_1_2_1_8_1","first-page":"220","article-title":"Uber den mechanismus der regenerationsprozess. III. Bleibt die polaritat der extremitat beim regenerationsprozess erhalten und die rolle der inneren teile des organs in diesem prozess","volume":"2","author":"Efimov M. E.","year":"1933","journal-title":"Biol. Zhur."},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02080341"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(74)80220-4"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.482926"},{"key":"e_1_2_1_12_1","first-page":"447","volume-title":"Mechanisms of Growth Control","author":"Libbin R. M.","year":"1981"},{"key":"e_1_2_1_13_1","first-page":"111A","article-title":"Regeneration of growth plates in the hindlimb of the rat","volume":"211","author":"Libbin R. M.","year":"1985","journal-title":"Anat. Rec."},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-4804(82)90071-3"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.3109\/10520297109067870"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1000650205"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmor.1051590308"},{"key":"e_1_2_1_18_1","first-page":"289","article-title":"On the mechanisms controlling the growth in length of the long bones","volume":"68","author":"Selye H.","year":"1934","journal-title":"J. Anat."},{"key":"e_1_2_1_19_1","unstructured":"Siverls V. C.1984Studies of the regeneration of the mammalian forelimb: healing and regeneration following forearm amputation with special reference to the status of the wound epidermis. M.S. Thesis Long Island University Graduate School Brooklyn NY."},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1000360206"},{"key":"e_1_2_1_21_1","first-page":"1","article-title":"Reconstitution d'un cartilage de croissance apr\u00e8s amputation","volume":"59","author":"Teucq E.","year":"1948","journal-title":"Arch. Biol."},{"key":"e_1_2_1_22_1","first-page":"495","article-title":"Does regenerative capacity decrease with age","volume":"4","author":"Zamaraev V. N.","year":"1974","journal-title":"Soviet J. Devel. Biol."}],"container-title":["American Journal of Anatomy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Faja.1001770307","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/aja.1001770307","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T12:42:51Z","timestamp":1697892171000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/aja.1001770307"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,11]]},"references-count":21,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1986,11]]}},"alternative-id":["10.1002\/aja.1001770307"],"URL":"https:\/\/doi.org\/10.1002\/aja.1001770307","archive":["Portico"],"relation":{},"ISSN":["0002-9106","1553-0795"],"issn-type":[{"value":"0002-9106","type":"print"},{"value":"1553-0795","type":"electronic"}],"subject":[],"published":{"date-parts":[[1986,11]]}}}