{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T10:18:42Z","timestamp":1772792322466,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,2,3]],"date-time":"2005-02-03T00:00:00Z","timestamp":1107388800000},"content-version":"vor","delay-in-days":6335,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Anat."],"published-print":{"date-parts":[[1987,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Fluid, particles, and cells are taken up from the peritoneal cavity by lymphatic drainage units, which, in the mouse and rat, are located along the peritoneal surface of the muscular portion of the diaphragm. The drainage units are composed of three specifically differentiated components: a lymphatic lacuna, a covering of lacunar mesothelium, and intervening submesothelial connective tissue. The units are drained by connecting lymphatic vessels that cross the diaphragm to empty into collecting lymphatic vessels running along the pleural surface of the diaphragm. The collecting lymphatics empty into parasternal lymphatic trunks. In this report, we briefly review critical features of the drainage apparatus and describe new observations, summarized below, about their structure.<\/jats:p><jats:p>Around the rim of stomata, the mesothelial openings that lead into the lymphatic lacunae, plasma membranes of lacunar mesothelial cells and of lacunar enidothelial cells abut but are not linked to one another by recognizable junctional specializations. Lacunarendothelial cells often extend valve\u2010like processes that bridge the distal end of the channel beneath the stoma. The configuration of the endothelial processes may be complex. Occasionally, processes from fibroblasts in the submesothelial connective tissue adjacent to stomata make contact with the interstitial surface of lacunar endothelial cells. A discontinuous elastic layer in the submesothelial connective tissue spans the roof of each lacuna. Connecting and collecting lymphatics, which drain lymphatic lacunae, possess endothelial valves. Possible functions for each of these newly described structural features are discussed.<\/jats:p>","DOI":"10.1002\/aja.1001800209","type":"journal-article","created":{"date-parts":[[2005,2,26]],"date-time":"2005-02-26T17:26:57Z","timestamp":1109438817000},"page":"195-207","source":"Crossref","is-referenced-by-count":61,"title":["Light and electron microscope observations of the lymphatic drainage units of the peritoneal cavity of rodents"],"prefix":"10.1002","volume":"180","author":[{"given":"Effy C.","family":"Tsilibary","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven L.","family":"Wissig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,2,3]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1090670110"},{"key":"e_1_2_1_3_1","first-page":"111","article-title":"Lymph flow mechanism of the subpcritoneal diaphragmatic lymphatics","volume":"11","author":"Bettendorf U.","year":"1978","journal-title":"Lymphology"},{"key":"e_1_2_1_4_1","first-page":"66","article-title":"Electronmicroscopic studies on the peritoneal resorption of intraperitoneally injected latex particles via the diaphragmatic lymphatics","volume":"12","author":"Bettendorf U.","year":"1979","journal-title":"Lymphology"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.37.2.244"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.1964.sp001743"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1979.59.1.1"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.1960.sp001448"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-9638-7"},{"key":"e_1_2_1_10_1","first-page":"137a","article-title":"A formaldehyde\u2010glutaraldehyde fixative of high osmolarity for use in electron micrdscopy","volume":"27","author":"Karnovsky M. J.","year":"1965","journal-title":"J. Cell Biol."},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.35.1.213"},{"key":"e_1_2_1_12_1","series-title":"Proc. 11th Ann. Meeting, Am. Soc. Cell Biol.","first-page":"146a","volume-title":"Use of ferrocyanide\u2010reduced osmium tetroxide in electron microscopy","author":"Karnovsky M. J.","year":"1971"},{"key":"e_1_2_1_13_1","first-page":"1863","article-title":"The structure of lymphatic capillaries in lymph formation","volume":"35","author":"Leak L. V.","year":"1979","journal-title":"Fed. Proc."},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.36.1.129"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001510409"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.5365.1107"},{"key":"e_1_2_1_17_1","first-page":"105","article-title":"On the mechanism of absorption of granular materials from the peritoneum","volume":"14","author":"McCallum W. G.","year":"1903","journal-title":"Bull. Johns Hopkins Hosp."},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.5387.885"},{"key":"e_1_2_1_19_1","first-page":"149","volume-title":"Modern Management of the Rh Problem","author":"Queenan J.","year":"1977"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5320(67)80239-9"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5320(68)80098-X"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1092130107"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.70.3.608"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5320(61)80011-7"},{"key":"e_1_2_1_25_1","unstructured":"Tsilibary E. C.(1980)Lymphatic absorption from the peritoneal cavity: A morphological study. Ph.D. Thesis University of California Sun Francisco."},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001490111"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/0026-2862(83)90041-9"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.25.2.407"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01930770"},{"key":"e_1_2_1_30_1","first-page":"12","article-title":"The preformed stomas connecting the pleural cavity and the lymphatics in the parietal pleura","volume":"111","author":"Wang N.\u2010S.","year":"1975","journal-title":"Am. Rev. Resp. Dis."},{"key":"e_1_2_1_31_1","first-page":"295","volume-title":"The pleural and peritoneal cavities","author":"Yoffey J. M.","year":"1970"}],"container-title":["American Journal of Anatomy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Faja.1001800209","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/aja.1001800209","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T23:08:09Z","timestamp":1697843289000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/aja.1001800209"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,10]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1987,10]]}},"alternative-id":["10.1002\/aja.1001800209"],"URL":"https:\/\/doi.org\/10.1002\/aja.1001800209","archive":["Portico"],"relation":{},"ISSN":["0002-9106","1553-0795"],"issn-type":[{"value":"0002-9106","type":"print"},{"value":"1553-0795","type":"electronic"}],"subject":[],"published":{"date-parts":[[1987,10]]}}}