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We examined microcirculatory pathways in normal human spleens freshly obtained from organ transplant donors. A modified corrosion casting procedure was used to obtain an open view of vessels and their connections. Our results demonstrate: (1) \u201earteriolar\u2010capillary bundles\u201d\ufe01 within lymphatic nodules and extensive branching of arterioles; in the marginal zone (MZ); (2) the marginal sinus around lymphatic nodules; (3) the peri\u2010marginal cavernous sinus (PMCS) outside the MZ or immediately adjacent to the nodule itself; the PMCS receives flow via ellipsoid sheaths and MZ, or directly from arterial capillaries, and drains into venous sinuses; (4) fast pathways for flow into venous sinuses via ellipsoid sheaths; (5) arterial capillary terminations in the reticular meshwork of the red pulp or MZ (\u201eopen\u201d\ufe01 circulation); direct connections to venous sinuses also occur (\u201eclosed\u201d\ufe01 circulation), although rarely; and (6) numerous open\u2010ended venous sinuses in the MZ, allowing a large proportion of the splenic inflow to bypass the red cell filtration sites in the reticular meshwork and at venous sinus walls.<\/jats:p>","DOI":"10.1002\/aja.1001810304","type":"journal-article","created":{"date-parts":[[2005,2,27]],"date-time":"2005-02-27T02:50:59Z","timestamp":1109472659000},"page":"253-266","source":"Crossref","is-referenced-by-count":31,"title":["Microcirculatory pathways in normal human spleen, demonstrated by scanning electron microscopy of corrosion casts"],"prefix":"10.1002","volume":"181","author":[{"given":"E. 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