{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T09:30:58Z","timestamp":1762075858940},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,2,3]],"date-time":"2005-02-03T00:00:00Z","timestamp":1107388800000},"content-version":"vor","delay-in-days":6122,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Anat."],"published-print":{"date-parts":[[1988,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Immunocytochemistry with protein A\u2010gold and routine electron microscopy were used to identify cell types within the endocrine pancreas of larvae, juvenile adults, and upstream\u2010migrant adults of the sea lamprey, <jats:italic>Petromyzon marinus.<\/jats:italic> The larval pancreatic islets are composed only of insulin\u2010immunoreactive B\u2010cells, which are uniform in their fine structure. The cranial and caudal pancreatic tissue in both adult periods contains three cell types: B\u2010cells, somatostatin\u2010immunoreactive D\u2010cells, and a third cell type of unknown content. No glucagon\u2010immunoreactive cells are present in lampreys, but B\u2010and D\u2010cells exist in equal numbers in the pancreatic tissue of adults. The B\u2010cells of adults have a fine structure similar to those in larvae. D\u2010cells have secretory granules that are distinctly different from those both in B\u2010cells and in the third cell type. Although B\u2010 and D\u2010cells in lamprey pancreatic tissues have a basic morphological similarity to these cells in other vertebrates, their granules are generally of smaller dimensions. The inclusion of granules within large pleomorphic bodies in many D\u2010cells indicates that granule turnover is common. Immunocytochemistry will be a useful tool for showing the relationship between the cells in the degenerating bile ducts and those of the developing adult pancreas.<\/jats:p>","DOI":"10.1002\/aja.1001820107","type":"journal-article","created":{"date-parts":[[2005,2,27]],"date-time":"2005-02-27T02:53:08Z","timestamp":1109472788000},"page":"73-83","source":"Crossref","is-referenced-by-count":19,"title":["Fine structure and immunocytochemistry of cells within the endocrine pancreas of larval and adult sea lampreys, <i>Petromyzon marinus<\/i> L."],"prefix":"10.1002","volume":"182","author":[{"given":"W. M.","family":"Elliott","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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