{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T13:40:09Z","timestamp":1697982009172},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,2,3]],"date-time":"2005-02-03T00:00:00Z","timestamp":1107388800000},"content-version":"vor","delay-in-days":6091,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Anat."],"published-print":{"date-parts":[[1988,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>CBA\/N mice carry an X\u2010linked immune\u2010deficiency gene, leading to a defect in the ability to form antibodies against T\u2010independent type 2 antigens. By using immunohistochemistry, the organization of the spleen of the immune\u2010deficient male (<jats:italic>xid<\/jats:italic>) CBA\/N F1 and the normal female F1 were compared. Staining with antilymphocyte markers showed that the total number of cells in the various T\u2010 and B\u2010cell areas was smaller in the <jats:italic>xid<\/jats:italic> mouse, resulting in very small white pulp compartments. Fewer B cells were seen in the marginal zone. When the spleens of the F1 mice were examined for macrophage markers, the rings of marginal\u2010zone macrophages and the ring of marginal metallophilic macrophages were much thinner in the <jats:italic>xid<\/jats:italic> mouse. In particular, the marginal\u2010zone macrophages are thought to play a role in the response against thymus\u2010independent type 2 antigens, and their small numbers in the <jats:italic>xid<\/jats:italic> mouse are suggestive of a role for the microenvironment in the defects in these mice.<\/jats:p>","DOI":"10.1002\/aja.1001820205","type":"journal-article","created":{"date-parts":[[2005,2,26]],"date-time":"2005-02-26T17:25:38Z","timestamp":1109438738000},"page":"148-154","source":"Crossref","is-referenced-by-count":9,"title":["Splenic microenvironment of the CBA\/N mouse: Immunohistochemical analysis using monoclonal antibodies against lymphocytes and nonlymphoid cells"],"prefix":"10.1002","volume":"182","author":[{"given":"Georg","family":"Kraal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karin","family":"Hoeben","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marga","family":"Janse","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,2,3]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.136.4.931"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830111013"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.152.5.1194"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-1759(84)90237-0"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830160505"},{"key":"e_1_2_1_7_1","first-page":"297","article-title":"High resolution enzyme localization with a new diazo reagent hexazonium pararosaniline","volume":"7","author":"Davis B. 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