{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T14:30:36Z","timestamp":1758637836543},"reference-count":33,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,2,3]],"date-time":"2005-02-03T00:00:00Z","timestamp":1107388800000},"content-version":"vor","delay-in-days":5969,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Anat."],"published-print":{"date-parts":[[1988,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The toothless (<jats:italic>tl<\/jats:italic>) rat is a nonlethal osteopetrotic mutation characterized by the presence of few osteoclasts and the failure to be cured by bone\u2010marrow transplantation. We examined the skeletal biology of <jats:italic>tl<\/jats:italic> rats and normal littermates up to 6 weeks after birth. Osteoclasts in <jats:italic>tl<\/jats:italic> rats were small, reduced 25\u2010fold in number, and had greatly reduced concentrations of acid hydrolases. Bone shape internally and externally reflected reduced bone resorption, and <jats:italic>tl<\/jats:italic> rats were hypophosphatemic and mildly hypocalcemic at 2 weeks. These data indicate that the basic defect in <jats:italic>tl<\/jats:italic> rats is one of differentiation of osteoclasts and, coupled with the observation that normal bone\u2010marrow cells cannot develop into osteoclasts in the <jats:italic>tl<\/jats:italic> skeleton, suggest that the defect lies in the skeletal microenvironment.<\/jats:p>","DOI":"10.1002\/aja.1001830206","type":"journal-article","created":{"date-parts":[[2005,2,26]],"date-time":"2005-02-26T16:54:15Z","timestamp":1109436855000},"page":"158-165","source":"Crossref","is-referenced-by-count":31,"title":["Skeletal biology in the toothless (osteopetrotic) rat"],"prefix":"10.1002","volume":"183","author":[{"given":"Mark F.","family":"Seifert","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven N.","family":"Popoff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"Sandy C.","family":"Marks","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,2,3]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(86)90541-2"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/34.3.3005390"},{"key":"e_1_2_1_4_1","unstructured":"Andersson G. N. S. C.MarksJr. B.Ek\u2010Rylander andL.Hammarstrom1988Osteoclastic acid ATPase\u2010biochemical and histochemical studies of the three osteopetrotic mutations in the rat.Bone Min. in press."},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","unstructured":"Andersson G. N. andS. C.MarksJr. 1988Tartrate\u2010resistant acid ATPase as a cytochemical marker for osteoclasts.J. Histochem. Cytochem. in press.","DOI":"10.1177\/37.1.2461980"},{"key":"e_1_2_1_6_1","first-page":"363","article-title":"Kinetic and cytochemical identification of osteoclast percursors and their differentiation into multinucleated osteoclasts","volume":"122","author":"Baron R.","year":"1986","journal-title":"Am. J. 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