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Graphic reconstructions were prepared from two particularly suitable examples, and mitotic figures were plotted for one of these. The lengths of the rostral and caudal neuropores are basically similar, but the rostral opening closes 1 day earlier and more abruptly (within a few hours) than the caudal (which takes a day). Closure of the rostral neuropore in the human embryo is bidirectional, proceeding simultaneously from (1) midbrain and diencephalon 2 and (2) the telencephalic region adjacent to the chiasmatic plate. Species differences are emphasized. Closure at the terminal lip of the neuropore is by fusion of right and left neural folds, as occurs elsewhere during primary neurulation. The rostral end of the neural plate in the median plane is, in the human embryo, at the rostral limit of the chiasmatic plate. Histological differences, however, exist between closure at the terminal lip and that at the dorsal lip: the surface epithelium plays a more significant role at the terminal lip, and the seam is more visible and presumably stronger. In future anencephaly it has been found that fusion at the terminal lip may occur, although that at the dorsal lip is deficient.<\/jats:p>","DOI":"10.1002\/aja.1001840402","type":"journal-article","created":{"date-parts":[[2005,2,26]],"date-time":"2005-02-26T16:57:22Z","timestamp":1109437042000},"page":"259-268","source":"Crossref","is-referenced-by-count":43,"title":["Bidirectional closure of the rostral neuropore in the human embryo"],"prefix":"10.1002","volume":"184","author":[{"given":"Ronan","family":"O'Rahilly","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabiola","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,2,3]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"13","article-title":"The early development of the human brain","volume":"37","author":"Bartelmez G. 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