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Recently completed accounts and reconstructions of the normal brains of staged human embryos served as controls for comparison with the abnormal examples. The embryos shared in common: holoprosenceph\u2010aly, arhinencephaly sensu stricto (absence of olfactory nerve fibers, bulbs, and tracts), presence of a proboscis, synophthalmia with two lens vesicles, a retarded telencephalic wall, absence of the mediobasal part of the telencephalon (the future septal area and the commissural plate: future anterior commissure and corpus callosum), irregularity of the diencephalon, mensural changes in the brain, absence of the rostral part of the noto\u2010chord and consequent cranial defects, and small ganglia of the cranial nerves. Where it could be determined (at least in the three less advanced specimens), the adenohypophysial primordium was either small and isolated or was absent; a ten\u2010torial condensation appeared to be missing; and disturbances of the primordia of the orbital muscles and their innervation were noted. The corpus striatum is single and corresponds to only the di\u2010encephalic part (medial eminence) of normal embryos. Interference with induction by the pre\u2010chordal plate at or before stage 8 (18 days) would be expected to affect the future mediobasal part of the neural plate (median prosencephalic dysgen\u2010esis) and the future optic primordium (cyclopia sensu stricto). Insufficient formation of material from the prechordal plate would account for disorders of the orbital musculature and, possibly, for inadequacy of the tentorium cerebelli. Disturbance a couple of days later (stage 9) would result in synophthalmia. Cyclopia and synophthalmia entail arhinencephaly and holoprosencephaly, both of which may arise independently. Defective distribution of the cephalic mesenchyme points to a derangement of the mesencephalic neural crest (stages 10 and 11), causing such features as an incomplete chondrocranium and reduction in size of the ganglia of the cranial nerves. Failure of bilateral division of the telencephalon would occur at or before 4 weeks (stages 13 and 14). It is concluded that all the above conditions arise during the first 4 postovulatory weeks.<\/jats:p>","DOI":"10.1002\/aja.1001850404","type":"journal-article","created":{"date-parts":[[2005,2,27]],"date-time":"2005-02-27T02:28:05Z","timestamp":1109471285000},"page":"391-414","source":"Crossref","is-referenced-by-count":53,"title":["Mediobasal prosencephalic defects, including holoprosencephaly and cyclopia, in relation to the development of the human forebrain"],"prefix":"10.1002","volume":"185","author":[{"given":"Fabiola","family":"M\u00fcller","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronan","family":"O'Rahilly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,2,3]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/jez.1400670203"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1086\/394504"},{"key":"e_1_2_1_4_1","first-page":"537","article-title":"Commissures t\u00e9lenc\u00e9phaliques chez le foetus de souris cycloc\u00e9phale","volume":"49","author":"Auroux M.","year":"1966","journal-title":"Arch. 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