{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T15:10:12Z","timestamp":1759849812326,"version":"build-2065373602"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,2,3]],"date-time":"2005-02-03T00:00:00Z","timestamp":1107388800000},"content-version":"vor","delay-in-days":4173,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Developmental Dynamics"],"published-print":{"date-parts":[[1993,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cultured stellate reticulum cells isolated from rat mandibular molars respond to incubation in EGF by increasing their level of expression of TGF\u2010\u03b2<jats:sub>1<\/jats:sub> mRNA. Northern blots showed that incubation in EGF for 6 hours stimulated over a two\u2010fold increase in TGF\u2010\u03b2<jats:sub>1<\/jats:sub> mRNA in the cells. In contrast, indicating that TGF\u2010\u03b2<jats:sub>1<\/jats:sub> does not have an autocrine effect on these cells. Immunocytochemistry showed that EGF receptor was present on the surface of many but not all of the cultured stellate reticulum cells. Because EGF does stimulate premature eruption of teeth, it is possible that its effect on the stellate reticulum region of the enamel organ would be to stimulate synthesis of TGF\u2010\u03b2<jats:sub>1<\/jats:sub> mRNA which, in turn, could lead to increased synthesis of TGF\u2010\u03b2<jats:sub>1<\/jats:sub> by these cells. The cells do contain the TGF\u2010\u03b2<jats:sub>1<\/jats:sub> protein as revealed by immunocytostaining. The newly synthesized TGF\u2010\u03b2<jats:sub>1<\/jats:sub> may exert its effect on the adjacent dental follicle to either initiate the onset of the cellular events of tooth eruption or to increase the secretion of extracellular matrix proteins by the follicle for formation of the periodontal ligament. \u00a9 1993 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/aja.1001980104","type":"journal-article","created":{"date-parts":[[2005,2,26]],"date-time":"2005-02-26T11:23:16Z","timestamp":1109416996000},"page":"22-27","source":"Crossref","is-referenced-by-count":9,"title":["Effect of epidermal growth factor on expression of transforming growth factor\u2010\u03b2<sub>1<\/sub> mRNA in stellate reticulum cells of rat mandibular molars"],"prefix":"10.1002","volume":"198","author":[{"given":"Fan","family":"Lin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary E.","family":"Wise","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,2,3]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"7155","DOI":"10.1016\/S0021-9258(18)32345-7","article-title":"Transforming growth factor\u2010beta in human platelets","volume":"258","author":"Assoian R. 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