{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T19:51:52Z","timestamp":1769025112503,"version":"3.49.0"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,2,3]],"date-time":"2005-02-03T00:00:00Z","timestamp":1107388800000},"content-version":"vor","delay-in-days":3443,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Developmental Dynamics"],"published-print":{"date-parts":[[1995,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Fibrillar networks are intimately involved in several morphogenetic processes which underlie the harmonious development of the vertebrate embryo. Recent genetic evidence has demonstrated that the minor types V and XI collagen are key regulators of types I and II fibrillogenesis in non\u2010cartilaginous and cartilaginous matrices, respectively. A comprehensive understanding of the expression and regulation of the genes coding for the chains of the minor collagen types is therefore relevant to animal morphogenesis and development. The present study was undertaken to elucidate the embryonic pattern of expression of the gene coding for the mouse \u03b11 chain of type XI colagen (<jats:italic>Col11\u03b11<\/jats:italic>) using the technique of in situ hybridization. Transcripts of the <jats:italic>Col11\u03b11<\/jats:italic> gene were detected as early as 11 days of gestation. The \u03b11(XI) transcripts were found to accumulate mostly in cartilaginous tissues, such as the chondrocranium and the developing limbs. Like the major cartilage\u2010specific collagen (type II), <jats:italic>Col11\u03b11<\/jats:italic> expression was also noted in the neuro\u2010epithelium of the brain. However, \u03b11(XI) transcripts accumulated in several other non\u2010cartilaginous sites. They include odontoblasts, trabecular bones, atrioventricular valve of the heart, the tongue, the intestine, and the otic vesicle. Altogether, the data confirm that <jats:italic>Col11\u03b11<\/jats:italic> has a broader spectrum of expression than previously thought. This finding raises the possibility that the \u03b11(XI) chain may participate in the formation of stage\u2010 and tissue\u2010specific trimers with distinct functional properties. \u00a9 1995 wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/aja.1002040106","type":"journal-article","created":{"date-parts":[[2005,2,26]],"date-time":"2005-02-26T20:52:49Z","timestamp":1109451169000},"page":"41-47","source":"Crossref","is-referenced-by-count":63,"title":["Developmental pattern of expression of the mouse \u03b11(XI) collagen gene (<i>Col11a1<\/i>)"],"prefix":"10.1002","volume":"204","author":[{"given":"Hidekatsu","family":"Yoshioka","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken\u2010Ichi","family":"Iyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhito","family":"Inoguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed","family":"Khaleduzzaman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshifumi","family":"Ninomiya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Ramirez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,2,3]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001950205"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0195-31"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"17159","DOI":"10.1016\/S0021-9258(18)37512-4","article-title":"Cloning and sequencing of pro\u2010\u03b11(XI) collagen cDNA demonstrates that type XI belongs to the fibrillar class of collagens and reveals that the expression of the gene is not restricted to cartilaginous tissue","volume":"263","author":"Bernard M.","year":"1988","journal-title":"J. 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Structure of the amino\u2010terminal propeptide and expression of the gene in tumor cell lines","volume":"265","author":"Yoshioka H.","year":"1990","journal-title":"J. Biol. Chem."},{"key":"e_1_2_1_33_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.1.418"},{"key":"e_1_2_1_34_1","doi-asserted-by":"crossref","unstructured":"Yoshioka H. Inoguchi K. Khaleduzzaman M. Ninomiya Y. 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