{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T05:36:05Z","timestamp":1791264965935,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,2,3]],"date-time":"2005-02-03T00:00:00Z","timestamp":1107388800000},"content-version":"vor","delay-in-days":3382,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Developmental Dynamics"],"published-print":{"date-parts":[[1995,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Three mouse homologues of the <jats:italic>Drosophila<\/jats:italic> homeotic gene <jats:italic>Caudal (Cad)<\/jats:italic> have been described. They are currently designated <jats:italic>Cdx<\/jats:italic>\u2010<jats:italic>1<\/jats:italic>, <jats:italic>Cdx<\/jats:italic>\u2010<jats:italic>2<\/jats:italic>, and <jats:italic>Cdx<\/jats:italic>\u2010<jats:italic>4<\/jats:italic>. <jats:italic>Cdx<\/jats:italic>\u2010<jats:italic>1<\/jats:italic> and <jats:italic>2<\/jats:italic> are both strongly expressed in the adult mid\u2010 and hindgut, while <jats:italic>Cdx<\/jats:italic>\u2010<jats:italic>1<\/jats:italic> and <jats:italic>4<\/jats:italic> have been shown to be activated in the embryonic primitive streak. Using a polyclonal antibody against a fusion protein containing the amino terminal 109 amino acids of murine Cdx\u20102, we here describe the topographical location of the gene product from early cleavage to 12.5 days of embryonic development. Cdx\u20102 expression begins at 3.5 days and is confined to the trophectoderm, being absent from the inner cell mass. Subsequently, staining is located in the extra\u2010embryonic ectoderm adjacent to the epiblast, but sparing the more superficially placed polar, as well as the mural trophoblastic cells. Continuing expression in the fetal membranes involves the chorion, the allantoic bud, and, at even later stages, the spongiotrophoblast. From 8.5 days, Cdx\u20102 begins to be expressed in embryonic tissues, principally (unlike Cdx\u20101) in the posterior part of the gut from its earliest formation, as well as in the tail bud and in the caudal part of the neural tube. <jats:italic>Cdx<\/jats:italic>\u2010<jats:italic>2<\/jats:italic> is, therefore, transcribed well before any other membrane of the <jats:italic>Cad<\/jats:italic> homologue group and of the related <jats:italic>Hox<\/jats:italic>\u2010C group; its expression in the extra\u2010embryonic membranes and in the hindgut reflects the phylogenetic relationship between the cloaca and the chorio\u2010allantois and suggests the possibility that homeobox genes may be involved in placental development and\/or patterning. \u00a9 1995 wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/aja.1002040302","type":"journal-article","created":{"date-parts":[[2005,2,26]],"date-time":"2005-02-26T21:02:06Z","timestamp":1109451726000},"page":"219-227","source":"Crossref","is-referenced-by-count":353,"title":["Expression of <i>Cdx\u20102<\/i> in the mouse embryo and placenta: Possible role in patterning of the extra\u2010embryonic membranes"],"prefix":"10.1002","volume":"204","author":[{"given":"F.","family":"Beck","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Erler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Russell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"James","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,2,3]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"153","volume-title":"Marshall's Physiology of Reproduction","author":"Amoroso E. 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