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In this cross\u2010sectional study, 80 middle\u2010aged and older (M\u2009=\u200954 years, SD\u2009=\u20097) Latino or Hispanic immigrants (51% male) living in the United States completed a series of questionnaires in Spanish. We performed multiple regression analyses to examine risk and protective factors for mental health outcomes. The results indicated that 86% of our participants reported experiencing at least one traumatic event in their lifetime (M\u2009=\u20095, SD\u2009=\u20096). Higher acculturative stress was associated with greater symptoms of depression, anxiety, and posttraumatic stress disorder. Greater levels of family support were found to be linked with lower symptoms of psychological distress, depression, and posttraumatic stress disorder symptoms. The cumulative exposure to traumatic events and acculturative stress across the lifespan impacts the mental health of aging Latino immigrants. 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