{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T22:11:21Z","timestamp":1773439881018,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2001,12,18]],"date-time":"2001-12-18T00:00:00Z","timestamp":1008633600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2002,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Complete remission can be achieved in 60\u201380% of adults with diffuse aggressive non\u2010Hodgkin's lymphoma. However, 20\u201340% of them will subsequently relapse. Nevertheless, formal follow\u2010up guidelines for recurrence detection have never been advocated. We analyzed the pattern of relapse in 30 patients with intermediate\u2010 and high\u2010grade non\u2010Hodgkin's lymphoma and the value of intensive protocol for relapse detection. This protocol includes frequent follow\u2010up visits, complete blood count, and serum LDH tests along with annual chest, abdominal, and pelvic CT scans. The median duration of complete remission was 12 months. Twenty\u2010five relapses (83%) were suspected after an interim history and \/or physical examination, whereas only 5 relapses (17%) were detected by routine radiographic or laboratory follow\u2010up studies. The majority of relapses (19\/30) were detected in sites that included the sites of prior disease. For the first 12 months of complete remission, the estimated cumulative save in charge for a follow\u2010up strategy, based on regular visits in the hematology clinic and performing laboratory and radiologic studies as clinically indicated, is 44% of the cost of a routine intensive evaluation. A reliable and cost\u2010effective follow\u2010up method for non\u2010Hodgkin's lymphoma patients in complete remission should include frequent history and physical examination. Complementary studies should be performed according to clinical indications. Am. J. Hematol. 69:41\u201344, 2002. \u00a9 2002 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajh.10017","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T22:17:27Z","timestamp":1030313847000},"page":"41-44","source":"Crossref","is-referenced-by-count":62,"title":["Detection of relapse in non\u2010Hodgkin's lymphoma: Role of routine follow\u2010up studies"],"prefix":"10.1002","volume":"69","author":[{"given":"Avishay","family":"Elis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorit","family":"Blickstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osnat","family":"Klein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rivka","family":"Eliav\u2010Ronen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yosef","family":"Manor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Lishner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,12,20]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"46","article-title":"Chemotherapy of non\u2010Hodgkin's aggressive lymphomas","volume":"31","author":"Salles G","year":"1994","journal-title":"Semin Hematol"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199304083281409"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1991.9.7.1196"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1497.1997.012005318.x"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19820515)49:10<2112::AID-CNCR2820491024>3.0.CO;2-2"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199309303291402"},{"key":"e_1_2_1_8_2","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1080\/00325481.1982.11716119","article-title":"The cured lymphoma patient. Guidelines for long term follow\u2010up","volume":"72","author":"Connors JM","year":"1982","journal-title":"Postgrad Med"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1999.17.4.1244"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1989.7.5.613"},{"key":"e_1_2_1_11_2","first-page":"307 (Abstract 8","article-title":"Utility of follow\u2010up tests for detecting disease recurrence of surgically resected primary malignant melanoma","volume":"14","author":"Weiss M","year":"1995","journal-title":"Proc Am Soc Clin Oncol"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/jso.2930340314"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199810013391407"},{"key":"e_1_2_1_14_2","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1001\/jama.1994.03510440047031","article-title":"Impact of follow\u2010up testing on survival and health\u2010related quality of life in breast cancer patients. A multicenter randomized controlled trial","volume":"271","author":"The Givio Investigators","year":"1994","journal-title":"J Am Med Assoc"},{"key":"e_1_2_1_15_2","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1001\/jama.1994.03510440053032","article-title":"Intensive diagnostic follow\u2010up after treatment of primary breast cancer","volume":"271","author":"Rosselli Del Turco M","year":"1994","journal-title":"J Am Med Assoc"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.1995.1262"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.1995.0012"},{"key":"e_1_2_1_18_2","first-page":"386 (Abstract 1","article-title":"Routine out\u2010patient review following treatment for Hodgkin's disease: is it an efficient way for detecting relapse?","volume":"14","author":"Radford JA","year":"1995","journal-title":"Proc Am Soc Clin Oncol"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1997.15.3.1123"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajh.10017","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.10017","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,18]],"date-time":"2023-11-18T10:51:03Z","timestamp":1700304663000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.10017"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,12,20]]},"references-count":18,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2002,1]]}},"alternative-id":["10.1002\/ajh.10017"],"URL":"https:\/\/doi.org\/10.1002\/ajh.10017","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,12,20]]}}}