{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T19:52:23Z","timestamp":1774122743265,"version":"3.50.1"},"reference-count":10,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2002,1,18]],"date-time":"2002-01-18T00:00:00Z","timestamp":1011312000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2002,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>P selectin is a component of endothelial Wiebel\u2010Palade body membrane and platelet alpha granule membrane. Patients with von Willebrand disease (VWD) have low plasma von Willebrand factor (VWF). To examine the relationship between plasma P selectin and VWF, both were measured by ELISA in 38 patients with VWD and 40 controls. The patient had lower VWF (<jats:italic>P<\/jats:italic> &lt; 0.001) but similar P selectin levels (<jats:italic>P<\/jats:italic> = 0.458). In 24 type 1 VWD patients, VWF and P selectin correlated inversely (<jats:italic>P<\/jats:italic> = 0.005) but in 14 type 2 VWD patients there was no correlation (<jats:italic>P<\/jats:italic> = 0.997). These data imply major differences in VWF\/P\u2010selectin regulation between types 1 and 2 VWD. Am. J. Hematol. 69:135\u2013137, 2002.\u00a9 2002 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajh.10025","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T23:45:33Z","timestamp":1030319133000},"page":"135-137","source":"Crossref","is-referenced-by-count":2,"title":["Inverse relationship between plasma von Willebrand factor and soluble P selectin in patients with type 1 but not type 2 von Willebrand disease"],"prefix":"10.1002","volume":"69","author":[{"given":"A.D.","family":"Blann","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.C.","family":"Nitu\u2010Whalley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.A.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.Y.H.","family":"Lip","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,1,18]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1055\/s-0038-1646169","article-title":"The Weibel\u2010Palade body: the storage granule for von Willebrand factor and P selectin","volume":"70","author":"Wagner DD","year":"1993","journal-title":"Thromb Haemost"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.101.3.880"},{"key":"e_1_2_1_4_2","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1055\/s-0037-1614447","article-title":"Post\u2010DDAVP thrombocytopenia in type 2B von Willebrand disease is not associated with platelet consumption: failure to demonstrate glycocalicin increase or platelet activation","volume":"81","author":"Casonato A","year":"1999","journal-title":"Thromb Haemostas"},{"key":"e_1_2_1_5_2","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1182\/blood.V83.6.1535.1535","article-title":"Plasma P selectin is increased in thrombotic consumptive platelet disorders","volume":"83","author":"Chong BH","year":"1994","journal-title":"Blood"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001721-200101000-00007"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9150(96)05980-1"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1996.5031040.x"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1159\/000044903"},{"key":"e_1_2_1_10_2","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1055\/s-0038-1642670","article-title":"Molecular mechanisms and classification of von Willebrand disease","volume":"74","author":"Sadler JE","year":"1995","journal-title":"Thromb Haemost"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1614162"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajh.10025","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.10025","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,7]],"date-time":"2023-10-07T08:35:39Z","timestamp":1696667739000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.10025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,1,18]]},"references-count":10,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2002,2]]}},"alternative-id":["10.1002\/ajh.10025"],"URL":"https:\/\/doi.org\/10.1002\/ajh.10025","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,1,18]]}}}